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Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study

PURPOSE: Recently, a cluster of pneumonia caused by SARS-CoV-2 were identified in Wuhan and spread throughout the world. More information about risk factors for mortality of critically ill patients infected with SARS-CoV-2 remain to be evaluated. METHODS: We included adult patients confirmed with SA...

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Autores principales: Gou, Luoning, Xiang, Ming, Ran, Xiao, Wang, Fen, Zhang, Shujun, Li, Shusheng, Dong, Kun, Chen, Xi, Huang, Yangxin, Meng, Chengzhen, Fan, Qian, Yang, Yan, Yu, Xuefeng, Ma, Delin, Yin, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800461/
https://www.ncbi.nlm.nih.gov/pubmed/33442281
http://dx.doi.org/10.2147/DMSO.S284148
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author Gou, Luoning
Xiang, Ming
Ran, Xiao
Wang, Fen
Zhang, Shujun
Li, Shusheng
Dong, Kun
Chen, Xi
Huang, Yangxin
Meng, Chengzhen
Fan, Qian
Yang, Yan
Yu, Xuefeng
Ma, Delin
Yin, Ping
author_facet Gou, Luoning
Xiang, Ming
Ran, Xiao
Wang, Fen
Zhang, Shujun
Li, Shusheng
Dong, Kun
Chen, Xi
Huang, Yangxin
Meng, Chengzhen
Fan, Qian
Yang, Yan
Yu, Xuefeng
Ma, Delin
Yin, Ping
author_sort Gou, Luoning
collection PubMed
description PURPOSE: Recently, a cluster of pneumonia caused by SARS-CoV-2 were identified in Wuhan and spread throughout the world. More information about risk factors for mortality of critically ill patients infected with SARS-CoV-2 remain to be evaluated. METHODS: We included adult patients confirmed with SARS-CoV-2 infection who were critically ill and admitted to the intensive care unit (ICU) of Tongji Hospital in Wuhan from Feb 4, 2020 to Feb 20, 2020. Data were collected and compared between patients who died and improved. Logistic regression was used to explore the risk factors for death of SARS-CoV-2-infected critically ill patients. RESULTS: A total of 160 critically ill patients with SARS-CoV-2 infection were included, of which 146 patients with appeared outcomes were included into the final analysis. The random blood glucose, serum sodium and effective plasma osmolarity were higher in deceased patients, especially in patients with diabetes. There were 7 patients with diabetes with hyperosmolar status and all of them were deceased. Multivariable regression revealed that older age (odds ratio 4.28, 95% CI 1.01–18.20; p = 0.049), higher C-reactive protein (odds ratio 1.01, 1.00–1.03; p = 0.024), higher interleukin-6 (odds ratio 1.01, 1.00–1.03; p = 0.0323), and d-dimer greater than 1 μg/mL (odds ratio 1.10, 1.01–1.20; p = 0.032) at admission were associated with increased odds of death. CONCLUSION: In conclusion, hyperosmolarity needs more attention and may contribute to mortality in critically ill patients with COVID-19, especially in those with diabetes. Older age, inflammatory response, and thrombosis may be risk factors for death of critically ill patients with SARS-CoV-2 infection.
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spelling pubmed-78004612021-01-12 Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study Gou, Luoning Xiang, Ming Ran, Xiao Wang, Fen Zhang, Shujun Li, Shusheng Dong, Kun Chen, Xi Huang, Yangxin Meng, Chengzhen Fan, Qian Yang, Yan Yu, Xuefeng Ma, Delin Yin, Ping Diabetes Metab Syndr Obes Original Research PURPOSE: Recently, a cluster of pneumonia caused by SARS-CoV-2 were identified in Wuhan and spread throughout the world. More information about risk factors for mortality of critically ill patients infected with SARS-CoV-2 remain to be evaluated. METHODS: We included adult patients confirmed with SARS-CoV-2 infection who were critically ill and admitted to the intensive care unit (ICU) of Tongji Hospital in Wuhan from Feb 4, 2020 to Feb 20, 2020. Data were collected and compared between patients who died and improved. Logistic regression was used to explore the risk factors for death of SARS-CoV-2-infected critically ill patients. RESULTS: A total of 160 critically ill patients with SARS-CoV-2 infection were included, of which 146 patients with appeared outcomes were included into the final analysis. The random blood glucose, serum sodium and effective plasma osmolarity were higher in deceased patients, especially in patients with diabetes. There were 7 patients with diabetes with hyperosmolar status and all of them were deceased. Multivariable regression revealed that older age (odds ratio 4.28, 95% CI 1.01–18.20; p = 0.049), higher C-reactive protein (odds ratio 1.01, 1.00–1.03; p = 0.024), higher interleukin-6 (odds ratio 1.01, 1.00–1.03; p = 0.0323), and d-dimer greater than 1 μg/mL (odds ratio 1.10, 1.01–1.20; p = 0.032) at admission were associated with increased odds of death. CONCLUSION: In conclusion, hyperosmolarity needs more attention and may contribute to mortality in critically ill patients with COVID-19, especially in those with diabetes. Older age, inflammatory response, and thrombosis may be risk factors for death of critically ill patients with SARS-CoV-2 infection. Dove 2021-01-07 /pmc/articles/PMC7800461/ /pubmed/33442281 http://dx.doi.org/10.2147/DMSO.S284148 Text en © 2021 Gou et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Gou, Luoning
Xiang, Ming
Ran, Xiao
Wang, Fen
Zhang, Shujun
Li, Shusheng
Dong, Kun
Chen, Xi
Huang, Yangxin
Meng, Chengzhen
Fan, Qian
Yang, Yan
Yu, Xuefeng
Ma, Delin
Yin, Ping
Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
title Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
title_full Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
title_fullStr Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
title_full_unstemmed Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
title_short Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
title_sort hyperosmolarity deserves more attention in critically ill covid-19 patients with diabetes: a cohort-based study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800461/
https://www.ncbi.nlm.nih.gov/pubmed/33442281
http://dx.doi.org/10.2147/DMSO.S284148
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