The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation

Metanephrines (MNs; normetanephrine (NMN), metanephrine (MN) and methoxytyramine (MT)) detected in urine or plasma represent the best biomarker for neuroblastoma (NB) diagnosis, however the metabolism of both catecholamine (CAT) and MNs remains enigmatic in NB. Using patient-derived xenograft (PDX)...

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Detalles Bibliográficos
Autores principales: Abid, Karim, Popovic, Maja Beck, Bourloud, Katia Balmas, Schoumans, Jacqueline, Grand-Guillaume, Joana, Grouzmann, Eric, Mühlethaler-Mottet, Annick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800772/
https://www.ncbi.nlm.nih.gov/pubmed/33456713
http://dx.doi.org/10.18632/oncotarget.27858

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