Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata

From a CHCl(3)-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activ...

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Detalles Bibliográficos
Autores principales: Dang, Phu H., Le, Tho H., Do, Truong N. V., Nguyen, Hai X., Nguyen, Mai T. T., Nguyen, Nhan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801053/
https://www.ncbi.nlm.nih.gov/pubmed/33488760
http://dx.doi.org/10.1155/2021/8872920
Descripción
Sumario:From a CHCl(3)-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC(50) values of 0.033 and 0.11 μM, respectively. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. Accordingly, semedienone (1) showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalkanoids was proposed.

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