The dark side of ferroptosis in pancreatic cancer

Drug-induced ferroptosis, an iron-dependent regulatory necrosis, has been proposed for the therapy of pancreatic ductal adenocarcinoma. However, genetically engineered mouse models have revealed that high-iron diets or deletion of pancreatic GPX4 (a key repressor of ferroptosis) accelerate the devel...

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Autores principales: Liu, Jiao, Dai, Enyong, Kang, Rui, Kroemer, Guido, Tang, Daolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801118/
https://www.ncbi.nlm.nih.gov/pubmed/33489473
http://dx.doi.org/10.1080/2162402X.2020.1868691
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author Liu, Jiao
Dai, Enyong
Kang, Rui
Kroemer, Guido
Tang, Daolin
author_facet Liu, Jiao
Dai, Enyong
Kang, Rui
Kroemer, Guido
Tang, Daolin
author_sort Liu, Jiao
collection PubMed
description Drug-induced ferroptosis, an iron-dependent regulatory necrosis, has been proposed for the therapy of pancreatic ductal adenocarcinoma. However, genetically engineered mouse models have revealed that high-iron diets or deletion of pancreatic GPX4 (a key repressor of ferroptosis) accelerate the development of mutant Kras-driven PDAC by activating the STING1/TMEM173-dependent DNA sensor pathway. Abbreviations ADM: acinar-to-ductal metaplasia; CGAS: cyclic GMP-AMP synthase; DAMP: damage-associated molecular pattern; GPX4: glutathione peroxidase 4; GEMM: genetically engineered mouse models; PDAC: pancreatic ductal adenocarcinoma; PanIN: pancreatic intraepithelial neoplasia, SLC7A11: solute carrier family 7 member 11; STING1: cGAMP-stimulator of interferon response cGAMP interactor 1; TME: tumor microenvironment; 8-OHG: 8-hydroxy-2ʹ-deoxyguanosine
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spelling pubmed-78011182021-01-21 The dark side of ferroptosis in pancreatic cancer Liu, Jiao Dai, Enyong Kang, Rui Kroemer, Guido Tang, Daolin Oncoimmunology Author View Drug-induced ferroptosis, an iron-dependent regulatory necrosis, has been proposed for the therapy of pancreatic ductal adenocarcinoma. However, genetically engineered mouse models have revealed that high-iron diets or deletion of pancreatic GPX4 (a key repressor of ferroptosis) accelerate the development of mutant Kras-driven PDAC by activating the STING1/TMEM173-dependent DNA sensor pathway. Abbreviations ADM: acinar-to-ductal metaplasia; CGAS: cyclic GMP-AMP synthase; DAMP: damage-associated molecular pattern; GPX4: glutathione peroxidase 4; GEMM: genetically engineered mouse models; PDAC: pancreatic ductal adenocarcinoma; PanIN: pancreatic intraepithelial neoplasia, SLC7A11: solute carrier family 7 member 11; STING1: cGAMP-stimulator of interferon response cGAMP interactor 1; TME: tumor microenvironment; 8-OHG: 8-hydroxy-2ʹ-deoxyguanosine Taylor & Francis 2021-01-04 /pmc/articles/PMC7801118/ /pubmed/33489473 http://dx.doi.org/10.1080/2162402X.2020.1868691 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author View
Liu, Jiao
Dai, Enyong
Kang, Rui
Kroemer, Guido
Tang, Daolin
The dark side of ferroptosis in pancreatic cancer
title The dark side of ferroptosis in pancreatic cancer
title_full The dark side of ferroptosis in pancreatic cancer
title_fullStr The dark side of ferroptosis in pancreatic cancer
title_full_unstemmed The dark side of ferroptosis in pancreatic cancer
title_short The dark side of ferroptosis in pancreatic cancer
title_sort dark side of ferroptosis in pancreatic cancer
topic Author View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801118/
https://www.ncbi.nlm.nih.gov/pubmed/33489473
http://dx.doi.org/10.1080/2162402X.2020.1868691
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