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Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer
Purpose: Bronchopleural fistula (BPF) is a potential serious complication of lobectomy or more radical surgery for non-small-cell lung cancer (NSCLC). We aimed to evaluate the risk factors for BPF. Methods: The study cohort comprised 635 patients who had undergone lobectomy or more radical surgery f...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801181/ https://www.ncbi.nlm.nih.gov/pubmed/32224595 http://dx.doi.org/10.5761/atcs.oa.20-00010 |
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author | Tokunaga, Yoshimasa Kita, Yusuke Okamoto, Taku |
author_facet | Tokunaga, Yoshimasa Kita, Yusuke Okamoto, Taku |
author_sort | Tokunaga, Yoshimasa |
collection | PubMed |
description | Purpose: Bronchopleural fistula (BPF) is a potential serious complication of lobectomy or more radical surgery for non-small-cell lung cancer (NSCLC). We aimed to evaluate the risk factors for BPF. Methods: The study cohort comprised 635 patients who had undergone lobectomy or more radical surgery for NSCLC from March 2005 to December 2017. We examined the following risk factors for BPF: surgical procedure, medical history, preoperative treatment, and surgical management. Results: In all, 10 patients (1.6%) had developed postoperative BPFs. Univariate logistic regression analysis showed that surgical procedure, medical history (arteriosclerosis obliterans [ASO]), and bronchial stump reinforcement were significant risk factors. Multivariate analysis showed that only surgical procedure (right lower lobectomy, p = 0.011, odds ratio = 17.4; right middle lower lobectomy, p = 0.003, odds ratio = 59.4; right pneumonectomy, p <0.001, odds ratio = 166.0) was a significant risk factor. Multivariate analysis confined to the surgical procedure of lobectomy showed that right lower lobectomy (p = 0.011, odds ratio = 36.5) and diabetes (HbA1c ≥8.0) (p = 0.022, odds ratio = 31.7) were significant risk factors. Conclusion: When lobectomy or more radical surgery is performed for NSCLC, right lower lobectomy, middle lower lobectomy, and right pneumonectomy are significant risk factors for postoperative BPF. Thoracic surgeons should acquire the techniques of bronchoplasty and angioplasty to avoid such invasive procedures. |
format | Online Article Text |
id | pubmed-7801181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-78011812021-01-15 Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer Tokunaga, Yoshimasa Kita, Yusuke Okamoto, Taku Ann Thorac Cardiovasc Surg Original Article Purpose: Bronchopleural fistula (BPF) is a potential serious complication of lobectomy or more radical surgery for non-small-cell lung cancer (NSCLC). We aimed to evaluate the risk factors for BPF. Methods: The study cohort comprised 635 patients who had undergone lobectomy or more radical surgery for NSCLC from March 2005 to December 2017. We examined the following risk factors for BPF: surgical procedure, medical history, preoperative treatment, and surgical management. Results: In all, 10 patients (1.6%) had developed postoperative BPFs. Univariate logistic regression analysis showed that surgical procedure, medical history (arteriosclerosis obliterans [ASO]), and bronchial stump reinforcement were significant risk factors. Multivariate analysis showed that only surgical procedure (right lower lobectomy, p = 0.011, odds ratio = 17.4; right middle lower lobectomy, p = 0.003, odds ratio = 59.4; right pneumonectomy, p <0.001, odds ratio = 166.0) was a significant risk factor. Multivariate analysis confined to the surgical procedure of lobectomy showed that right lower lobectomy (p = 0.011, odds ratio = 36.5) and diabetes (HbA1c ≥8.0) (p = 0.022, odds ratio = 31.7) were significant risk factors. Conclusion: When lobectomy or more radical surgery is performed for NSCLC, right lower lobectomy, middle lower lobectomy, and right pneumonectomy are significant risk factors for postoperative BPF. Thoracic surgeons should acquire the techniques of bronchoplasty and angioplasty to avoid such invasive procedures. The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2020-03-27 2020 /pmc/articles/PMC7801181/ /pubmed/32224595 http://dx.doi.org/10.5761/atcs.oa.20-00010 Text en ©2020 Annals of Thoracic and Cardiovascular Surgery http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NonDerivatives International License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Article Tokunaga, Yoshimasa Kita, Yusuke Okamoto, Taku Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer |
title | Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer |
title_full | Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer |
title_fullStr | Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer |
title_full_unstemmed | Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer |
title_short | Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer |
title_sort | analysis of risk factors for bronchopleural fistula after surgical treatment of lung cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801181/ https://www.ncbi.nlm.nih.gov/pubmed/32224595 http://dx.doi.org/10.5761/atcs.oa.20-00010 |
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