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Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry
OBJECTIVES: To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. METHODS: A cohort study of laboratory-confirmed COVID-19 patients who were hospitalized from March 2020 to September 2020 in 25 h...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801187/ https://www.ncbi.nlm.nih.gov/pubmed/33444752 http://dx.doi.org/10.1016/j.ijid.2021.01.019 |
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author | Marcolino, Milena S. Ziegelmann, Patricia K. Souza-Silva, Maira V.R. Nascimento, I.J.B. Oliveira, Luana M. Monteiro, Luanna S. Sales, Thaís L.S. Ruschel, Karen B. Martins, Karina P.M.P. Etges, Ana Paula B.S. Molina, Israel Polanczyk, Carisi A. |
author_facet | Marcolino, Milena S. Ziegelmann, Patricia K. Souza-Silva, Maira V.R. Nascimento, I.J.B. Oliveira, Luana M. Monteiro, Luanna S. Sales, Thaís L.S. Ruschel, Karen B. Martins, Karina P.M.P. Etges, Ana Paula B.S. Molina, Israel Polanczyk, Carisi A. |
author_sort | Marcolino, Milena S. |
collection | PubMed |
description | OBJECTIVES: To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. METHODS: A cohort study of laboratory-confirmed COVID-19 patients who were hospitalized from March 2020 to September 2020 in 25 hospitals. Data were collected from medical records using Research Electronic Data Capture (REDCap) tools. A multivariate Poisson regression model was used to assess the risk factors for in-hospital mortality. RESULTS: For a total of 2,054 patients (52.6% male; median age of 58 years), the in-hospital mortality was 22.0%; this rose to 47.6% for those treated in the intensive care unit (ICU). Hypertension (52.9%), diabetes (29.2%), and obesity (17.2%) were the most prevalent comorbidities. Overall, 32.5% required invasive mechanical ventilation, and 12.1% required kidney replacement therapy. Septic shock was observed in 15.0%, nosocomial infection in 13.1%, thromboembolism in 4.1%, and acute heart failure in 3.6%. Age >= 65 years, chronic kidney disease, hypertension, C-reactive protein ≥ 100 mg/dL, platelet count < 100 × 10(9)/L, oxygen saturation < 90%, the need for supplemental oxygen, and invasive mechanical ventilation at admission were independently associated with a higher risk of in-hospital mortality. The overall use of antimicrobials was 87.9%. CONCLUSIONS: This study reveals the characteristics and in-hospital outcomes of hospitalized patients with confirmed COVID-19 in Brazil. Certain easily assessed parameters at hospital admission were independently associated with a higher risk of death. The high frequency of antibiotic use points to an over-use of antimicrobials in COVID-19 patients. |
format | Online Article Text |
id | pubmed-7801187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78011872021-01-12 Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry Marcolino, Milena S. Ziegelmann, Patricia K. Souza-Silva, Maira V.R. Nascimento, I.J.B. Oliveira, Luana M. Monteiro, Luanna S. Sales, Thaís L.S. Ruschel, Karen B. Martins, Karina P.M.P. Etges, Ana Paula B.S. Molina, Israel Polanczyk, Carisi A. Int J Infect Dis Article OBJECTIVES: To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. METHODS: A cohort study of laboratory-confirmed COVID-19 patients who were hospitalized from March 2020 to September 2020 in 25 hospitals. Data were collected from medical records using Research Electronic Data Capture (REDCap) tools. A multivariate Poisson regression model was used to assess the risk factors for in-hospital mortality. RESULTS: For a total of 2,054 patients (52.6% male; median age of 58 years), the in-hospital mortality was 22.0%; this rose to 47.6% for those treated in the intensive care unit (ICU). Hypertension (52.9%), diabetes (29.2%), and obesity (17.2%) were the most prevalent comorbidities. Overall, 32.5% required invasive mechanical ventilation, and 12.1% required kidney replacement therapy. Septic shock was observed in 15.0%, nosocomial infection in 13.1%, thromboembolism in 4.1%, and acute heart failure in 3.6%. Age >= 65 years, chronic kidney disease, hypertension, C-reactive protein ≥ 100 mg/dL, platelet count < 100 × 10(9)/L, oxygen saturation < 90%, the need for supplemental oxygen, and invasive mechanical ventilation at admission were independently associated with a higher risk of in-hospital mortality. The overall use of antimicrobials was 87.9%. CONCLUSIONS: This study reveals the characteristics and in-hospital outcomes of hospitalized patients with confirmed COVID-19 in Brazil. Certain easily assessed parameters at hospital admission were independently associated with a higher risk of death. The high frequency of antibiotic use points to an over-use of antimicrobials in COVID-19 patients. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-06 2021-01-12 /pmc/articles/PMC7801187/ /pubmed/33444752 http://dx.doi.org/10.1016/j.ijid.2021.01.019 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Marcolino, Milena S. Ziegelmann, Patricia K. Souza-Silva, Maira V.R. Nascimento, I.J.B. Oliveira, Luana M. Monteiro, Luanna S. Sales, Thaís L.S. Ruschel, Karen B. Martins, Karina P.M.P. Etges, Ana Paula B.S. Molina, Israel Polanczyk, Carisi A. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry |
title | Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry |
title_full | Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry |
title_fullStr | Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry |
title_full_unstemmed | Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry |
title_short | Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry |
title_sort | clinical characteristics and outcomes of patients hospitalized with covid-19 in brazil: results from the brazilian covid-19 registry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801187/ https://www.ncbi.nlm.nih.gov/pubmed/33444752 http://dx.doi.org/10.1016/j.ijid.2021.01.019 |
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