Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure–response analysis

PURPOSE: This study assessed the effect of lurbinectedin, a highly selective inhibitor of oncogenic transcription, on the change from baseline in Fridericia’s corrected QT interval (∆QTcF) and electrocardiography (ECG) morphological patterns, and lurbinectedin concentration–∆QTcF (C-∆QTcF) relations...

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Detalles Bibliográficos
Autores principales: Fudio, Salvador, Tabernero, Josep, Subbiah, Vivek, Chawla, Sant P., Moreno, Victor, Longo, Federico, Lopez, Rafael, Anton, Antonio, Trigo, Jose Manuel, Shapiro, Geoffrey, Jeong, Woondong, Villalobos, Victor Manuel, Lubomirov, Rubin, Fernandez-Teruel, Carlos, Alfaro, Vicente, Boni, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801313/
https://www.ncbi.nlm.nih.gov/pubmed/33108504
http://dx.doi.org/10.1007/s00280-020-04153-6

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