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A new certified reference material for size and shape analysis of nanorods using electron microscopy
A new certified reference material (CRM) for size and shape analysis of elongated nanoparticles has been developed by the European Commission’s Joint Research Centre. The CRM consists of titanium dioxide nanorods dispersed in 1-butanol, was coded ERM-FD103 and has been certified for different electr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801322/ https://www.ncbi.nlm.nih.gov/pubmed/33048174 http://dx.doi.org/10.1007/s00216-020-02984-z |
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author | Kestens, Vikram Gerganova, Tsvetelina Roebben, Gert Held, Andrea |
author_facet | Kestens, Vikram Gerganova, Tsvetelina Roebben, Gert Held, Andrea |
author_sort | Kestens, Vikram |
collection | PubMed |
description | A new certified reference material (CRM) for size and shape analysis of elongated nanoparticles has been developed by the European Commission’s Joint Research Centre. The CRM consists of titanium dioxide nanorods dispersed in 1-butanol, was coded ERM-FD103 and has been certified for different electron microscopy–based operationally defined measurands such as the modal and median values of the particle number-weighted distributions of the minimum and maximum Feret diameter, the maximum inscribed circle diameter, the area-equivalent circular diameter and the aspect ratio. The nanorods have nominal dimensions of 15 nm in width and 55 nm in length. Homogeneity and stability measurements were performed using transmission electron microscopy. The relative standard uncertainty for homogeneity ranged from 0.3 to 1.7%. No significant instability was detected for a shelf life of 18 months and a storage temperature of 18 °C. The certified values have been determined from the results of an interlaboratory comparison in which qualified expert laboratories participated with scanning and transmission electron microscopy. The certified values are traceable to the unit of length in the International System of Units, the metre, and the relative expanded uncertainties (confidence level of approximately 95%) range from 4 to 6%. These properties allow the CRM to be used for quality assurance and calibration of electron microscopy methods for nanoparticle size and shape analysis in ranges relevant for the implementation of EU legislation related to nanomaterials. The presented study discusses the purpose and results of the different steps that were followed to turn an industrially relevant raw titanium dioxide nanorod material into a fit-for-purpose CRM. Graphical abstract [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00216-020-02984-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7801322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-78013222021-01-21 A new certified reference material for size and shape analysis of nanorods using electron microscopy Kestens, Vikram Gerganova, Tsvetelina Roebben, Gert Held, Andrea Anal Bioanal Chem Research Paper A new certified reference material (CRM) for size and shape analysis of elongated nanoparticles has been developed by the European Commission’s Joint Research Centre. The CRM consists of titanium dioxide nanorods dispersed in 1-butanol, was coded ERM-FD103 and has been certified for different electron microscopy–based operationally defined measurands such as the modal and median values of the particle number-weighted distributions of the minimum and maximum Feret diameter, the maximum inscribed circle diameter, the area-equivalent circular diameter and the aspect ratio. The nanorods have nominal dimensions of 15 nm in width and 55 nm in length. Homogeneity and stability measurements were performed using transmission electron microscopy. The relative standard uncertainty for homogeneity ranged from 0.3 to 1.7%. No significant instability was detected for a shelf life of 18 months and a storage temperature of 18 °C. The certified values have been determined from the results of an interlaboratory comparison in which qualified expert laboratories participated with scanning and transmission electron microscopy. The certified values are traceable to the unit of length in the International System of Units, the metre, and the relative expanded uncertainties (confidence level of approximately 95%) range from 4 to 6%. These properties allow the CRM to be used for quality assurance and calibration of electron microscopy methods for nanoparticle size and shape analysis in ranges relevant for the implementation of EU legislation related to nanomaterials. The presented study discusses the purpose and results of the different steps that were followed to turn an industrially relevant raw titanium dioxide nanorod material into a fit-for-purpose CRM. Graphical abstract [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00216-020-02984-z) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-10-13 2021 /pmc/articles/PMC7801322/ /pubmed/33048174 http://dx.doi.org/10.1007/s00216-020-02984-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Paper Kestens, Vikram Gerganova, Tsvetelina Roebben, Gert Held, Andrea A new certified reference material for size and shape analysis of nanorods using electron microscopy |
title | A new certified reference material for size and shape analysis of nanorods using electron microscopy |
title_full | A new certified reference material for size and shape analysis of nanorods using electron microscopy |
title_fullStr | A new certified reference material for size and shape analysis of nanorods using electron microscopy |
title_full_unstemmed | A new certified reference material for size and shape analysis of nanorods using electron microscopy |
title_short | A new certified reference material for size and shape analysis of nanorods using electron microscopy |
title_sort | new certified reference material for size and shape analysis of nanorods using electron microscopy |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801322/ https://www.ncbi.nlm.nih.gov/pubmed/33048174 http://dx.doi.org/10.1007/s00216-020-02984-z |
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