Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations

D-2-hydroxyglutarate dehydrogenase (D-2-HGDH) catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) into 2-oxoglutarate, and genetic D-2-HGDH deficiency leads to abnormal accumulation of D-2-HG which causes type I D-2-hydroxyglutaric aciduria and is associated with diffuse large B-cell lymphoma....

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Detalles Bibliográficos
Autores principales: Yang, Jun, Zhu, Hanwen, Zhang, Tianlong, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801405/
https://www.ncbi.nlm.nih.gov/pubmed/33431826
http://dx.doi.org/10.1038/s41421-020-00227-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801405/
https://www.ncbi.nlm.nih.gov/pubmed/33431826
http://dx.doi.org/10.1038/s41421-020-00227-0

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