Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

Legumain is required for maintenance of normal kidney homeostasis. However, its role in acute kidney injury (AKI) is still unclear. Here, we induced AKI by bilateral ischemia-reperfusion injury (IRI) of renal arteries or folic acid in lgmn(WT) and lgmn(KO) mice. We assessed serum creatinine, blood u...

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Detalles Bibliográficos
Autores principales: Chen, Chuan’ai, Wang, Dekun, Yu, Yangyang, Zhao, Tianyuan, Min, Ningning, Wu, Yan, Kang, Lichun, Zhao, Yong, Du, Lingfang, Zhang, Mianzhi, Gong, Junbo, Zhang, Zhujun, Zhang, Yuying, Mi, Xue, Yue, Shijing, Tan, Xiaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801434/
https://www.ncbi.nlm.nih.gov/pubmed/33431801
http://dx.doi.org/10.1038/s41419-020-03362-4

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