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Transformer neural network for protein-specific de novo drug generation as a machine translation problem

Drug discovery for a protein target is a very laborious, long and costly process. Machine learning approaches and, in particular, deep generative networks can substantially reduce development time and costs. However, the majority of methods imply prior knowledge of protein binders, their physicochem...

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Detalles Bibliográficos
Autor principal: Grechishnikova, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801439/
https://www.ncbi.nlm.nih.gov/pubmed/33432013
http://dx.doi.org/10.1038/s41598-020-79682-4

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