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Engineering of a bona fide light-operated calcium channel

The current optogenetic toolkit lacks a robust single-component Ca(2+)-selective ion channel tailored for remote control of Ca(2+) signaling in mammals. Existing tools are either derived from engineered channelrhodopsin variants without strict Ca(2+) selectivity or based on the stromal interaction m...

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Detalles Bibliográficos
Autores principales:	He, Lian, Wang, Liuqing, Zeng, Hongxiang, Tan, Peng, Ma, Guolin, Zheng, Sisi, Li, Yaxin, Sun, Lin, Dou, Fei, Siwko, Stefan, Huang, Yun, Wang, Youjun, Zhou, Yubin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801460/ https://www.ncbi.nlm.nih.gov/pubmed/33431868 http://dx.doi.org/10.1038/s41467-020-20425-4

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