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Stream-specific feedback inputs to the primate primary visual cortex

The sensory neocortex consists of hierarchically-organized areas reciprocally connected via feedforward and feedback circuits. Feedforward connections shape the receptive field properties of neurons in higher areas within parallel streams specialized in processing specific stimulus attributes. Feedb...

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Autores principales: Federer, Frederick, Ta’afua, Seminare, Merlin, Sam, Hassanpour, Mahlega S., Angelucci, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801467/
https://www.ncbi.nlm.nih.gov/pubmed/33431862
http://dx.doi.org/10.1038/s41467-020-20505-5
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author Federer, Frederick
Ta’afua, Seminare
Merlin, Sam
Hassanpour, Mahlega S.
Angelucci, Alessandra
author_facet Federer, Frederick
Ta’afua, Seminare
Merlin, Sam
Hassanpour, Mahlega S.
Angelucci, Alessandra
author_sort Federer, Frederick
collection PubMed
description The sensory neocortex consists of hierarchically-organized areas reciprocally connected via feedforward and feedback circuits. Feedforward connections shape the receptive field properties of neurons in higher areas within parallel streams specialized in processing specific stimulus attributes. Feedback connections have been implicated in top-down modulations, such as attention, prediction and sensory context. However, their computational role remains unknown, partly because we lack knowledge about rules of feedback connectivity to constrain models of feedback function. For example, it is unknown whether feedback connections maintain stream-specific segregation, or integrate information across parallel streams. Using viral-mediated labeling of feedback connections arising from specific cytochrome-oxidase stripes of macaque visual area V2, here we show that feedback to the primary visual cortex (V1) is organized into parallel streams resembling the reciprocal feedforward pathways. This suggests that functionally-specialized V2 feedback channels modulate V1 responses to specific stimulus attributes, an organizational principle potentially extending to feedback pathways in other sensory systems.
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spelling pubmed-78014672021-01-21 Stream-specific feedback inputs to the primate primary visual cortex Federer, Frederick Ta’afua, Seminare Merlin, Sam Hassanpour, Mahlega S. Angelucci, Alessandra Nat Commun Article The sensory neocortex consists of hierarchically-organized areas reciprocally connected via feedforward and feedback circuits. Feedforward connections shape the receptive field properties of neurons in higher areas within parallel streams specialized in processing specific stimulus attributes. Feedback connections have been implicated in top-down modulations, such as attention, prediction and sensory context. However, their computational role remains unknown, partly because we lack knowledge about rules of feedback connectivity to constrain models of feedback function. For example, it is unknown whether feedback connections maintain stream-specific segregation, or integrate information across parallel streams. Using viral-mediated labeling of feedback connections arising from specific cytochrome-oxidase stripes of macaque visual area V2, here we show that feedback to the primary visual cortex (V1) is organized into parallel streams resembling the reciprocal feedforward pathways. This suggests that functionally-specialized V2 feedback channels modulate V1 responses to specific stimulus attributes, an organizational principle potentially extending to feedback pathways in other sensory systems. Nature Publishing Group UK 2021-01-11 /pmc/articles/PMC7801467/ /pubmed/33431862 http://dx.doi.org/10.1038/s41467-020-20505-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Federer, Frederick
Ta’afua, Seminare
Merlin, Sam
Hassanpour, Mahlega S.
Angelucci, Alessandra
Stream-specific feedback inputs to the primate primary visual cortex
title Stream-specific feedback inputs to the primate primary visual cortex
title_full Stream-specific feedback inputs to the primate primary visual cortex
title_fullStr Stream-specific feedback inputs to the primate primary visual cortex
title_full_unstemmed Stream-specific feedback inputs to the primate primary visual cortex
title_short Stream-specific feedback inputs to the primate primary visual cortex
title_sort stream-specific feedback inputs to the primate primary visual cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801467/
https://www.ncbi.nlm.nih.gov/pubmed/33431862
http://dx.doi.org/10.1038/s41467-020-20505-5
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