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Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells

The PI3K/AKT/mTOR signaling pathway is constitutively active in PTEN-deficient cancer cells, and its targeted inhibition has significant anti-tumor effects. However, the efficacy of targeted therapies is often limited due to drug resistance. The relevant signaling pathways in PTEN-deficient cancer c...

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Detalles Bibliográficos
Autores principales:	Wang, Jian, Lv, Xiaoye, Guo, Xiutian, Dong, Yanbo, Peng, Peipei, Huang, Fang, Wang, Peng, Zhang, Haoqian, Zhou, Jianguang, Wang, Youliang, Wei, Bo, Shang, Zeng-Fu, Li, Shanhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801611/ https://www.ncbi.nlm.nih.gov/pubmed/33431808 http://dx.doi.org/10.1038/s41389-020-00292-w

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