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Ethanol exposure drives colon location specific cell composition changes in a normal colon crypt 3D organoid model

Alcohol is a consistently identified risk factor for colon cancer. However, the molecular mechanism underlying its effect on normal colon crypt cells remains poorly understood. We employed RNA-sequencing to asses transcriptomic response to ethanol exposure (0.2% vol:vol) in 3D organoid lines derived...

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Detalles Bibliográficos
Autores principales:	Devall, Matthew, Plummer, Sarah J., Bryant, Jennifer, Jennelle, Lucas T., Eaton, Stephen, Dampier, Christopher H., Huyghe, Jeroen R., Peters, Ulrike, Powell, Steven M., Casey, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801615/ https://www.ncbi.nlm.nih.gov/pubmed/33432071 http://dx.doi.org/10.1038/s41598-020-80240-1

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