Mtu1 defects are correlated with reduced osteogenic differentiation

Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful mesenchymal stem cell (MSC) differentiation. In the present study, the researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiatio...

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Autores principales: He, Qiufen, Zhao, Qiong, Li, Qianqian, Pan, Ruolang, Li, Xiongfeng, Chen, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801634/
https://www.ncbi.nlm.nih.gov/pubmed/33431792
http://dx.doi.org/10.1038/s41419-020-03345-5
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author He, Qiufen
Zhao, Qiong
Li, Qianqian
Pan, Ruolang
Li, Xiongfeng
Chen, Ye
author_facet He, Qiufen
Zhao, Qiong
Li, Qianqian
Pan, Ruolang
Li, Xiongfeng
Chen, Ye
author_sort He, Qiufen
collection PubMed
description Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful mesenchymal stem cell (MSC) differentiation. In the present study, the researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation. Using in vitro cultured bone marrow MSCs and stromal cell line MS5, we demonstrated that depressed Mtu1 expression was associated with reduced 2-thiouridine modification of the U34 of mitochondrial tRNA(Gln), tRNA(Glu), and tRNA(Lys), which led to respiratory deficiencies and reduced mitochondrial ATP production, and finally suppressed osteogenic differentiation. As expected, these Mtu1-deficient mice exhibited obvious osteopenia. Therefore, our findings in this study provide new insights into the pathophysiology of osteopenia.
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spelling pubmed-78016342021-01-21 Mtu1 defects are correlated with reduced osteogenic differentiation He, Qiufen Zhao, Qiong Li, Qianqian Pan, Ruolang Li, Xiongfeng Chen, Ye Cell Death Dis Article Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful mesenchymal stem cell (MSC) differentiation. In the present study, the researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation. Using in vitro cultured bone marrow MSCs and stromal cell line MS5, we demonstrated that depressed Mtu1 expression was associated with reduced 2-thiouridine modification of the U34 of mitochondrial tRNA(Gln), tRNA(Glu), and tRNA(Lys), which led to respiratory deficiencies and reduced mitochondrial ATP production, and finally suppressed osteogenic differentiation. As expected, these Mtu1-deficient mice exhibited obvious osteopenia. Therefore, our findings in this study provide new insights into the pathophysiology of osteopenia. Nature Publishing Group UK 2021-01-11 /pmc/articles/PMC7801634/ /pubmed/33431792 http://dx.doi.org/10.1038/s41419-020-03345-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
He, Qiufen
Zhao, Qiong
Li, Qianqian
Pan, Ruolang
Li, Xiongfeng
Chen, Ye
Mtu1 defects are correlated with reduced osteogenic differentiation
title Mtu1 defects are correlated with reduced osteogenic differentiation
title_full Mtu1 defects are correlated with reduced osteogenic differentiation
title_fullStr Mtu1 defects are correlated with reduced osteogenic differentiation
title_full_unstemmed Mtu1 defects are correlated with reduced osteogenic differentiation
title_short Mtu1 defects are correlated with reduced osteogenic differentiation
title_sort mtu1 defects are correlated with reduced osteogenic differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801634/
https://www.ncbi.nlm.nih.gov/pubmed/33431792
http://dx.doi.org/10.1038/s41419-020-03345-5
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AT panruolang mtu1defectsarecorrelatedwithreducedosteogenicdifferentiation
AT lixiongfeng mtu1defectsarecorrelatedwithreducedosteogenicdifferentiation
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