Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial and phenotypic immune-ITH from multiple tumour sectors and decipher its relationship with tumour evolution and disease...

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Detalles Bibliográficos
Autores principales: Nguyen, Phuong H. D., Ma, Siming, Phua, Cheryl Z. J., Kaya, Neslihan A., Lai, Hannah L. H., Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony K. H., Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred W. C., Young Dan, Yock, Chung, Alexander, Goh, Brian K. P., Albani, Salvatore, Chow, Pierce K. H., Zhai, Weiwei, Chew, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801667/
https://www.ncbi.nlm.nih.gov/pubmed/33431814
http://dx.doi.org/10.1038/s41467-020-20171-7

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