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Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice
MicroRNAs are short non-coding RNAs that negatively regulate protein levels and perform important roles in establishing and maintaining neuronal network function. Previous studies in adult rodents have detected upregulation of microRNA-134 after prolonged seizures (status epilepticus) and demonstrat...
Autores principales: | Campbell, Aoife, Morris, Gareth, Heller, Janosch P., Langa, Elena, Brindley, Elizabeth, Worm, Jesper, Jensen, Mads Aaboe, Miller, Meghan T., Henshall, David C., Reschke, Cristina R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801672/ https://www.ncbi.nlm.nih.gov/pubmed/33431894 http://dx.doi.org/10.1038/s41598-020-79350-7 |
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