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Effect of CYP2C19 genotypes on tamoxifen metabolism and early-breast cancer relapse

CYP2C19*2 and CYP2C19*17 might influence tamoxifen metabolism and clinical outcome. Our aim was to investigate the effect of CYP2C19 genotypes on tamoxifen concentrations and metabolic ratios (MRs) and breast cancer recurrence in a large cohort of Caucasian women. Genetic variants (CYP2D6 and CYP2C1...

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Detalles Bibliográficos
Autores principales:	Sanchez-Spitman, A. B., Swen, J. J., Dezentjé, V. O., Moes, D. J. A. R., Gelderblom, H., Guchelaar, H. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801676/ https://www.ncbi.nlm.nih.gov/pubmed/33432065 http://dx.doi.org/10.1038/s41598-020-79972-x

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