Combinatorial analyses reveal cellular composition changes have different impacts on transcriptomic changes of cell type specific genes in Alzheimer’s Disease

Alzheimer’s disease (AD) brains are characterized by progressive neuron loss and gliosis. Previous studies of gene expression using bulk tissue samples often fail to consider changes in cell-type composition when comparing AD versus control, which can lead to differences in expression levels that ar...

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Detalles Bibliográficos
Autores principales: Johnson, Travis S., Xiang, Shunian, Dong, Tianhan, Huang, Zhi, Cheng, Michael, Wang, Tianfu, Yang, Kai, Ni, Dong, Huang, Kun, Zhang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801680/
https://www.ncbi.nlm.nih.gov/pubmed/33432017
http://dx.doi.org/10.1038/s41598-020-79740-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801680/
https://www.ncbi.nlm.nih.gov/pubmed/33432017
http://dx.doi.org/10.1038/s41598-020-79740-x

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