Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring

Maternal metabolism dysregulation during pregnancy predisposes offspring to major diseases, including hypertension, in later life, but the mechanism involved remains to be fully elucidated. A high-fat-diet (HFD) pregnant rat model was used to investigate whether excessive intrauterine lipid exposure...

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Detalles Bibliográficos
Autores principales: Lin, Xian-Hua, Gao, Ling, Tian, Shen, Klausen, Christian, Guo, Meng-Xi, Gao, Qian, Liu, Miao-E., Wang, Hui, Wu, Dan-Dan, Zhou, Cheng-Liang, Yang, Jing, Meng, Ye, Liu, Ye, Xu, Gu-Feng, Tan, Ya-Jing, Ullah, Kamran, Zhu, Yi-Min, Fraser, William D., Sheng, Jian-Zhong, Leung, Peter C. K., Muglia, Louis J., Wu, Yan-Ting, Huang, He-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801715/
https://www.ncbi.nlm.nih.gov/pubmed/33431976
http://dx.doi.org/10.1038/s41598-020-79604-4

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