Progress in the total synthesis of inthomycins

The inthomycin family of antibiotics, isolated from Streptomyces strains, are interesting molecules for synthesis due to their characteristic common oxazole polyene chiral allylic β-hydroxycarbonyl fragments and significant biological activities. The full structural motif of the inthomycins is found...

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Autor principal: Senapati, Bidyut Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801802/
https://www.ncbi.nlm.nih.gov/pubmed/33488832
http://dx.doi.org/10.3762/bjoc.17.7
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author Senapati, Bidyut Kumar
author_facet Senapati, Bidyut Kumar
author_sort Senapati, Bidyut Kumar
collection PubMed
description The inthomycin family of antibiotics, isolated from Streptomyces strains, are interesting molecules for synthesis due to their characteristic common oxazole polyene chiral allylic β-hydroxycarbonyl fragments and significant biological activities. The full structural motif of the inthomycins is found in several more complex natural products including the oxazolomycins, 16-methyloxazolomycin, curromycins A and B, and KSM-2690. This review summarises the application of various efforts towards the synthesis of inthomycins and their analogues systematically.
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spelling pubmed-78018022021-01-22 Progress in the total synthesis of inthomycins Senapati, Bidyut Kumar Beilstein J Org Chem Review The inthomycin family of antibiotics, isolated from Streptomyces strains, are interesting molecules for synthesis due to their characteristic common oxazole polyene chiral allylic β-hydroxycarbonyl fragments and significant biological activities. The full structural motif of the inthomycins is found in several more complex natural products including the oxazolomycins, 16-methyloxazolomycin, curromycins A and B, and KSM-2690. This review summarises the application of various efforts towards the synthesis of inthomycins and their analogues systematically. Beilstein-Institut 2021-01-07 /pmc/articles/PMC7801802/ /pubmed/33488832 http://dx.doi.org/10.3762/bjoc.17.7 Text en Copyright © 2021, Senapati https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)
spellingShingle Review
Senapati, Bidyut Kumar
Progress in the total synthesis of inthomycins
title Progress in the total synthesis of inthomycins
title_full Progress in the total synthesis of inthomycins
title_fullStr Progress in the total synthesis of inthomycins
title_full_unstemmed Progress in the total synthesis of inthomycins
title_short Progress in the total synthesis of inthomycins
title_sort progress in the total synthesis of inthomycins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801802/
https://www.ncbi.nlm.nih.gov/pubmed/33488832
http://dx.doi.org/10.3762/bjoc.17.7
work_keys_str_mv AT senapatibidyutkumar progressinthetotalsynthesisofinthomycins

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