Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome

Most children with COVID-19 have asymptomatic or mild illness. Those who become critically ill suffer from acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI). The rapid deterioration of lung function has been linked to microangiopathic and immune-mediated processes seen in the...

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Autores principales: Raghunandan, Sharmila, Josephson, Cassandra D., Verkerke, Hans, Linam, W. Matthew, Ingram, Treva C., Zerra, Patricia E., Arthur, Connie M., Stowell, Sean R., Briones, Michael, Chonat, Satheesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802050/
https://www.ncbi.nlm.nih.gov/pubmed/33447586
http://dx.doi.org/10.3389/fped.2020.616731
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author Raghunandan, Sharmila
Josephson, Cassandra D.
Verkerke, Hans
Linam, W. Matthew
Ingram, Treva C.
Zerra, Patricia E.
Arthur, Connie M.
Stowell, Sean R.
Briones, Michael
Chonat, Satheesh
author_facet Raghunandan, Sharmila
Josephson, Cassandra D.
Verkerke, Hans
Linam, W. Matthew
Ingram, Treva C.
Zerra, Patricia E.
Arthur, Connie M.
Stowell, Sean R.
Briones, Michael
Chonat, Satheesh
author_sort Raghunandan, Sharmila
collection PubMed
description Most children with COVID-19 have asymptomatic or mild illness. Those who become critically ill suffer from acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI). The rapid deterioration of lung function has been linked to microangiopathic and immune-mediated processes seen in the lungs of adult patients with COVID-19. The role of complement-mediated acute lung injury is supported by animal models of SARS-CoV, evaluation of lung tissue in those who died from COVID-19 and response of COVID-19 ARDS to complement inhibition. We present a summary of a child with COVID-19 disease treated with convalescent plasma and eculizumab and provide a detailed evaluation of the inflammatory pathways.
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spelling pubmed-78020502021-01-13 Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome Raghunandan, Sharmila Josephson, Cassandra D. Verkerke, Hans Linam, W. Matthew Ingram, Treva C. Zerra, Patricia E. Arthur, Connie M. Stowell, Sean R. Briones, Michael Chonat, Satheesh Front Pediatr Pediatrics Most children with COVID-19 have asymptomatic or mild illness. Those who become critically ill suffer from acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI). The rapid deterioration of lung function has been linked to microangiopathic and immune-mediated processes seen in the lungs of adult patients with COVID-19. The role of complement-mediated acute lung injury is supported by animal models of SARS-CoV, evaluation of lung tissue in those who died from COVID-19 and response of COVID-19 ARDS to complement inhibition. We present a summary of a child with COVID-19 disease treated with convalescent plasma and eculizumab and provide a detailed evaluation of the inflammatory pathways. Frontiers Media S.A. 2020-12-29 /pmc/articles/PMC7802050/ /pubmed/33447586 http://dx.doi.org/10.3389/fped.2020.616731 Text en Copyright © 2020 Raghunandan, Josephson, Verkerke, Linam, Ingram, Zerra, Arthur, Stowell, Briones and Chonat. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Raghunandan, Sharmila
Josephson, Cassandra D.
Verkerke, Hans
Linam, W. Matthew
Ingram, Treva C.
Zerra, Patricia E.
Arthur, Connie M.
Stowell, Sean R.
Briones, Michael
Chonat, Satheesh
Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome
title Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome
title_full Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome
title_fullStr Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome
title_full_unstemmed Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome
title_short Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome
title_sort complement inhibition in severe covid-19 acute respiratory distress syndrome
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802050/
https://www.ncbi.nlm.nih.gov/pubmed/33447586
http://dx.doi.org/10.3389/fped.2020.616731
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