Cargando…

MicroRNA-149 is downregulated in Alzheimer’s disease and inhibits β-amyloid accumulation and ameliorates neuronal viability through targeting BACE1

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) plays a critical role in Alzheimer’s disease (AD) pathogenesis. This study aimed to investigate the relationship between microRNA-149 (miR-149) and BACE1, and evaluate the clinical significance and biological function of miR-149 in AD pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Wenyan, Lei, Chengbin, Dong, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Genética 2021
Materias:	Human and Medical Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802068/ https://www.ncbi.nlm.nih.gov/pubmed/33428703 http://dx.doi.org/10.1590/1415-4757-GMB-2020-0064

Ejemplares similares

Identification of microRNA signature in different pediatric brain tumors
por: Tantawy, Marwa, et al.
Publicado: (2018)

Circular RNA circENTPD7 suppresses the accumulation of PTEN to promote cell proliferation in non-small cell lung cancer
por: Yu, Hongwei, et al.
Publicado: (2022)

Characterization of the 3'UTR of the BTD gene and identification of regulatory elements and microRNAs
por: Silva, Gerda Cristal Villalba, et al.
Publicado: (2022)

The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer’s disease
por: dos Santos, Lígia Ramos, et al.
Publicado: (2020)

MicroRNA-296-5p is differentially expressed in individuals with and without HIV-1 infection
por: Cárdenas-Bedoya, Jhonathan, et al.
Publicado: (2020)

Influence of a genetic variant of CHAT gene over the profile of plasma soluble ChAT in Alzheimer disease
por: Rocha-Dias, Patricia Fernanda, et al.
Publicado: (2020)

Interleukin-8-251T > A, Interleukin-1α-889C > T and Apolipoprotein E polymorphisms in Alzheimer’s disease
por: Vendramini, Alex Augusto, et al.
Publicado: (2011)

Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer’s Disease patients: A pilot study
por: González-Castañeda, Rocío E., et al.
Publicado: (2013)

A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population
por: Brincas, Heloisa Magagnin, et al.
Publicado: (2020)

A tale of two drug targets: the evolutionary history of BACE1 and BACE2
por: Southan, Christopher, et al.
Publicado: (2013)

Diplazium esculentum (Retz.) Sw. reduces BACE-1 activities and amyloid peptides accumulation in Drosophila models of Alzheimer’s disease
por: Kunkeaw, Thanit, et al.
Publicado: (2021)

Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity
por: Jantrapirom, Salinee, et al.
Publicado: (2020)

Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease
por: Grimmer, Timo, et al.
Publicado: (2012)

Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome()
por: Mok, Kin Y., et al.
Publicado: (2014)

Simultaneous quantitative assessment of circulating cell-free mitochondrial and nuclear DNA by multiplex real-time PCR
por: Xia, Peng, et al.
Publicado: (2009)

Estimating genomic instability mediated by Alu retroelements in breast cancer
por: Fazza, Ana Cristina, et al.
Publicado: (2009)

Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
por: Gao, Lin, et al.
Publicado: (2009)

Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians
por: Boldt, Angelica B. W., et al.
Publicado: (2009)

Genetic signatures of parental contribution in black and white populations in Brazil
por: Guerreiro-Junior, Vanderlei, et al.
Publicado: (2009)

Relationship of an hRAD54 gene polymorphism (2290 C/T) in an Ecuadorian population with chronic myelogenous leukemia
por: Paz-y-Miño, César, et al.
Publicado: (2010)

In silico analysis of alpha1-antitrypsin variants: The effects of a novel mutation
por: Denden, Sabri, et al.
Publicado: (2010)

Interactions of polymorphisms in different clock genes associated with circadian phenotypes in humans
por: Pedrazzoli, Mario, et al.
Publicado: (2010)

The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
por: Cimponeriu, Danut, et al.
Publicado: (2010)

Polymorphisms in promoter sequences of MDM2, p53, and p16(INK4a) genes in normal Japanese individuals
por: Ohsaka, Yasuhito, et al.
Publicado: (2010)

DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients
por: Santos, Raquel A., et al.
Publicado: (2010)

Identification and characterization of two critical sequences in SV40PolyA that activate the green fluorescent protein reporter gene
por: Wang, Honggang, et al.
Publicado: (2011)

Combination of two rare mutations causes β-thalassaemia in a Bangladeshi patient
por: Moosa, Mahdi Muhammad, et al.
Publicado: (2011)

Mucopolysaccharidoses in northern Brazil: Targeted mutation screening and urinary glycosaminoglycan excretion in patients undergoing enzyme replacement therapy
por: Viana, Gustavo M., et al.
Publicado: (2011)

Genotype-phenotype correlation in cystic fibrosis patients bearing [H939R;H949L] allele
por: Polizzi, Angela, et al.
Publicado: (2011)

Determination of β(S) haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
por: Cabral, Cynthia Hatsue Kitayama, et al.
Publicado: (2011)

Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil
por: da Silveira, Zama Messala Luna, et al.
Publicado: (2011)

Research of the origin of a particular Tunisian group using a physical marker and Alu insertion polymorphisms
por: El Moncer, Wifak, et al.
Publicado: (2011)

Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
por: Lins, Tulio C., et al.
Publicado: (2011)

Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C
por: Jiao, Yan, et al.
Publicado: (2011)

Chromosome 19p13.3 deletion in a child with Peutz-Jeghers syndrome, congenital heart defect, high myopia, learning difficulties and dysmorphic features: Clinical and molecular characterization of a new contiguous gene syndrome
por: Souza, Josiane, et al.
Publicado: (2011)

Mutational analysis of xenobiotic metabolizing genes (CYP1A1 and GSTP1) in sporadic head and neck cancer patients
por: Masood, Nosheen, et al.
Publicado: (2011)

Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
por: Fontes, Aparecida Maria, et al.
Publicado: (2011)

Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: Application of the additive model for cancer
por: Pérez-Morales, Rebeca, et al.
Publicado: (2011)

Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension
por: Nejatizadeh, Azim, et al.
Publicado: (2011)

Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
por: de Oliveira Hiragi, Cássia, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_gl3rqo9hdcs8sfd61c57pesr29