Cargando…
Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase
[Image: see text] Current chemotherapeutics for leishmaniasis have multiple deficiencies, and there is a need for new safe, efficacious, and affordable medicines. This study describes a successful drug repurposing approach that identifies the over-the-counter antihistamine, clemastine fumarate, as a...
Autores principales: | Mina, John G. M., Charlton, Rebecca L., Alpizar-Sosa, Edubiel, Escrivani, Douglas O., Brown, Christopher, Alqaisi, Amjed, Borsodi, Maria Paula G., Figueiredo, Claudia P., de Lima, Emanuelle V., Dickie, Emily A., Wei, Wenbin, Coutinho-Silva, Robson, Merritt, Andy, Smith, Terry K., Barrett, Michael P., Rossi-Bergmann, Bartira, Denny, Paul W., Steel, Patrick G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802075/ https://www.ncbi.nlm.nih.gov/pubmed/33291887 http://dx.doi.org/10.1021/acsinfecdis.0c00546 |
Ejemplares similares
-
The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity
por: Pinneh, Elizabeth C., et al.
Publicado: (2019) -
Expression levels of inositol phosphorylceramide synthase modulate plant responses to biotic and abiotic stress in Arabidopsis thaliana
por: Pinneh, Elizabeth C., et al.
Publicado: (2019) -
Chalcones identify cTXNPx as a potential antileishmanial drug target
por: Escrivani, Douglas O., et al.
Publicado: (2021) -
Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity
por: Dos Santos, Nailma S A, et al.
Publicado: (2023) -
Leishmania (Viannia) braziliensis Inositol Phosphorylceramide: Distinctive Sphingoid Base Composition
por: De Castro Levatti, Erica V., et al.
Publicado: (2017)