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Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis

OBJECTIVES: To evaluate the prognostic factors affecting graft survival in patients undergoing penetrating keratoplasty (PKP) for infectious keratitis. MATERIALS AND METHODS: Patients who underwent PKP for keratitis in our hospital between 2013 and 2018 were retrospectively reviewed. Patients who un...

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Autores principales: Gümüş, Gülşah, Kırgız, Ahmet, Yıldırım, Yusuf, Kandemir Beşek, Nilay, Genç, Selim, Kepez Yıldız, Burçin, Taşkapılı, Muhittin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802093/
https://www.ncbi.nlm.nih.gov/pubmed/33389931
http://dx.doi.org/10.4274/tjo.galenos.2020.35305
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author Gümüş, Gülşah
Kırgız, Ahmet
Yıldırım, Yusuf
Kandemir Beşek, Nilay
Genç, Selim
Kepez Yıldız, Burçin
Taşkapılı, Muhittin
author_facet Gümüş, Gülşah
Kırgız, Ahmet
Yıldırım, Yusuf
Kandemir Beşek, Nilay
Genç, Selim
Kepez Yıldız, Burçin
Taşkapılı, Muhittin
author_sort Gümüş, Gülşah
collection PubMed
description OBJECTIVES: To evaluate the prognostic factors affecting graft survival in patients undergoing penetrating keratoplasty (PKP) for infectious keratitis. MATERIALS AND METHODS: Patients who underwent PKP for keratitis in our hospital between 2013 and 2018 were retrospectively reviewed. Patients who underwent therapeutic PKP at the inflammatory stage and were followed for at least 12 months were included in the study. Age, gender, follow-up period, time between diagnosis and surgery, lens status, presence of limbal involvement, presence of corneal ulceration, perforation, or corneal abscess, type of microorganism detected in culture, number of fortified medications used before surgery and duration of use, preoperative and postoperative visual acuity, postoperative graft transparency, postoperative complications, recurrence of infection, rate of re-keratoplasty, and indication for and timing of re-keratoplasty were recorded. The relationship between these findings and anatomic, therapeutic, and functional success were evaluated. RESULTS: Fifty-nine patients were included in the study; 40 (67.8%) were male and 19 (32.2%) were female, and the mean age was 59.78±19.46 (6-91) years. Anatomic success was achieved in 58 patients (98.3%). Therapeutic success was achieved in 47 patients (79.7%) and there was a significant relationship between therapeutic success and re-keratoplasty and early re-keratoplasty (p<0.001 for both). Thirty-two patients (54.2%) had functional success and there was a significant relationship between the absence of postoperative complications and functional success (p=0.014). CONCLUSION: PKP is an effective treatment option in treatment-resistant keratitis or keratitis with impending perforation. The absence of postoperative complications and performing early re-keratoplasty in patients with recurrence increase the success rate.
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spelling pubmed-78020932021-01-21 Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis Gümüş, Gülşah Kırgız, Ahmet Yıldırım, Yusuf Kandemir Beşek, Nilay Genç, Selim Kepez Yıldız, Burçin Taşkapılı, Muhittin Turk J Ophthalmol Original Article OBJECTIVES: To evaluate the prognostic factors affecting graft survival in patients undergoing penetrating keratoplasty (PKP) for infectious keratitis. MATERIALS AND METHODS: Patients who underwent PKP for keratitis in our hospital between 2013 and 2018 were retrospectively reviewed. Patients who underwent therapeutic PKP at the inflammatory stage and were followed for at least 12 months were included in the study. Age, gender, follow-up period, time between diagnosis and surgery, lens status, presence of limbal involvement, presence of corneal ulceration, perforation, or corneal abscess, type of microorganism detected in culture, number of fortified medications used before surgery and duration of use, preoperative and postoperative visual acuity, postoperative graft transparency, postoperative complications, recurrence of infection, rate of re-keratoplasty, and indication for and timing of re-keratoplasty were recorded. The relationship between these findings and anatomic, therapeutic, and functional success were evaluated. RESULTS: Fifty-nine patients were included in the study; 40 (67.8%) were male and 19 (32.2%) were female, and the mean age was 59.78±19.46 (6-91) years. Anatomic success was achieved in 58 patients (98.3%). Therapeutic success was achieved in 47 patients (79.7%) and there was a significant relationship between therapeutic success and re-keratoplasty and early re-keratoplasty (p<0.001 for both). Thirty-two patients (54.2%) had functional success and there was a significant relationship between the absence of postoperative complications and functional success (p=0.014). CONCLUSION: PKP is an effective treatment option in treatment-resistant keratitis or keratitis with impending perforation. The absence of postoperative complications and performing early re-keratoplasty in patients with recurrence increase the success rate. Galenos Publishing 2020-12 2020-12-29 /pmc/articles/PMC7802093/ /pubmed/33389931 http://dx.doi.org/10.4274/tjo.galenos.2020.35305 Text en © Copyright 2020 by Turkish Ophthalmological Association | Turkish Journal of Ophthalmology, published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Gümüş, Gülşah
Kırgız, Ahmet
Yıldırım, Yusuf
Kandemir Beşek, Nilay
Genç, Selim
Kepez Yıldız, Burçin
Taşkapılı, Muhittin
Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis
title Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis
title_full Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis
title_fullStr Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis
title_full_unstemmed Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis
title_short Prognostic Factors Affecting Graft Survival in Patients Undergoing Penetrating Keratoplasty for Infectious Keratitis
title_sort prognostic factors affecting graft survival in patients undergoing penetrating keratoplasty for infectious keratitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802093/
https://www.ncbi.nlm.nih.gov/pubmed/33389931
http://dx.doi.org/10.4274/tjo.galenos.2020.35305
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