Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications

Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned m...

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Autores principales: Gholami, Leila, Nooshabadi, Vajihe Taghdiri, Shahabi, Shiva, Jazayeri, Marzieh, Tarzemany, Rana, Afsartala, Zohreh, Khorsandi, Khatereh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802187/
https://www.ncbi.nlm.nih.gov/pubmed/33436061
http://dx.doi.org/10.1186/s13578-020-00527-8
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author Gholami, Leila
Nooshabadi, Vajihe Taghdiri
Shahabi, Shiva
Jazayeri, Marzieh
Tarzemany, Rana
Afsartala, Zohreh
Khorsandi, Khatereh
author_facet Gholami, Leila
Nooshabadi, Vajihe Taghdiri
Shahabi, Shiva
Jazayeri, Marzieh
Tarzemany, Rana
Afsartala, Zohreh
Khorsandi, Khatereh
author_sort Gholami, Leila
collection PubMed
description Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs’ EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects.
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spelling pubmed-78021872021-01-12 Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications Gholami, Leila Nooshabadi, Vajihe Taghdiri Shahabi, Shiva Jazayeri, Marzieh Tarzemany, Rana Afsartala, Zohreh Khorsandi, Khatereh Cell Biosci Review Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs’ EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects. BioMed Central 2021-01-12 /pmc/articles/PMC7802187/ /pubmed/33436061 http://dx.doi.org/10.1186/s13578-020-00527-8 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Gholami, Leila
Nooshabadi, Vajihe Taghdiri
Shahabi, Shiva
Jazayeri, Marzieh
Tarzemany, Rana
Afsartala, Zohreh
Khorsandi, Khatereh
Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
title Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
title_full Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
title_fullStr Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
title_full_unstemmed Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
title_short Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
title_sort extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802187/
https://www.ncbi.nlm.nih.gov/pubmed/33436061
http://dx.doi.org/10.1186/s13578-020-00527-8
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