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Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity
BACKGROUND: Bisphenol exposure is widespread and correlated with diabetes and cardiovascular disease. Previous intervention studies have successfully lowered bisphenol exposure among women of normal weight. The primary objective of this study was to develop and test the feasibility of a 3-week behav...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802296/ https://www.ncbi.nlm.nih.gov/pubmed/33436090 http://dx.doi.org/10.1186/s40814-020-00744-5 |
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author | Hagobian, Todd Delli-Bovi, Zoe Mercado, Adrian Bird, Alyssa Guy, Megan Phelan, Suzanne |
author_facet | Hagobian, Todd Delli-Bovi, Zoe Mercado, Adrian Bird, Alyssa Guy, Megan Phelan, Suzanne |
author_sort | Hagobian, Todd |
collection | PubMed |
description | BACKGROUND: Bisphenol exposure is widespread and correlated with diabetes and cardiovascular disease. Previous intervention studies have successfully lowered bisphenol exposure among women of normal weight. The primary objective of this study was to develop and test the feasibility of a 3-week behavioral change intervention, rooted in social cognitive theory, to lower a broad range of bisphenols (BPA, BPS, and BPF) in women with obesity. METHODS: Thirty women with obesity (31.1 ± 5.6 kg/m(2), 21.1 ± 3.1 years) were randomly assigned to an intervention or control. The intervention included weekly face-to-face meetings to reduce bisphenol exposures from food, cosmetics, and packaged products. Fasting urinary bisphenols, creatinine, and weight were assessed at study entry and after 3 weeks. RESULTS: The intervention was evaluated as feasible (100% of enrollment and recruitment, 96% of retention and attendance at lesson plan visits, and 96% of a collection of urine samples). Adherence to the intervention was estimated based on completion of self-monitoring records; the number of daily records completed was 7.7 ± 1.3 (mean ± SD) after week 1, 7.1 ± 1.5 after week 2, and 4.4 ± 0.9 after week 3. In secondary analysis, there was a significant treatment × time effect on creatinine-corrected urinary BPS (− 1.42 μg/g creatinine in the intervention vs. − 0.09 μg/g creatinine in the control group). CONCLUSION: In women with obesity, the 3-week intervention was considered feasible with promising preliminary results of decreasing BPS concentrations. These data warrant future large-scale clinical trial interventions to reduce bisphenol exposure and determine whether reductions in bisphenols positively impact diabetes and cardiovascular disease risk markers. This study was retroactively registered at ClinicalTrial.gov Identifier NCT03440307. |
format | Online Article Text |
id | pubmed-7802296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78022962021-01-13 Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity Hagobian, Todd Delli-Bovi, Zoe Mercado, Adrian Bird, Alyssa Guy, Megan Phelan, Suzanne Pilot Feasibility Stud Research BACKGROUND: Bisphenol exposure is widespread and correlated with diabetes and cardiovascular disease. Previous intervention studies have successfully lowered bisphenol exposure among women of normal weight. The primary objective of this study was to develop and test the feasibility of a 3-week behavioral change intervention, rooted in social cognitive theory, to lower a broad range of bisphenols (BPA, BPS, and BPF) in women with obesity. METHODS: Thirty women with obesity (31.1 ± 5.6 kg/m(2), 21.1 ± 3.1 years) were randomly assigned to an intervention or control. The intervention included weekly face-to-face meetings to reduce bisphenol exposures from food, cosmetics, and packaged products. Fasting urinary bisphenols, creatinine, and weight were assessed at study entry and after 3 weeks. RESULTS: The intervention was evaluated as feasible (100% of enrollment and recruitment, 96% of retention and attendance at lesson plan visits, and 96% of a collection of urine samples). Adherence to the intervention was estimated based on completion of self-monitoring records; the number of daily records completed was 7.7 ± 1.3 (mean ± SD) after week 1, 7.1 ± 1.5 after week 2, and 4.4 ± 0.9 after week 3. In secondary analysis, there was a significant treatment × time effect on creatinine-corrected urinary BPS (− 1.42 μg/g creatinine in the intervention vs. − 0.09 μg/g creatinine in the control group). CONCLUSION: In women with obesity, the 3-week intervention was considered feasible with promising preliminary results of decreasing BPS concentrations. These data warrant future large-scale clinical trial interventions to reduce bisphenol exposure and determine whether reductions in bisphenols positively impact diabetes and cardiovascular disease risk markers. This study was retroactively registered at ClinicalTrial.gov Identifier NCT03440307. BioMed Central 2021-01-12 /pmc/articles/PMC7802296/ /pubmed/33436090 http://dx.doi.org/10.1186/s40814-020-00744-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Hagobian, Todd Delli-Bovi, Zoe Mercado, Adrian Bird, Alyssa Guy, Megan Phelan, Suzanne Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity |
title | Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity |
title_full | Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity |
title_fullStr | Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity |
title_full_unstemmed | Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity |
title_short | Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity |
title_sort | development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802296/ https://www.ncbi.nlm.nih.gov/pubmed/33436090 http://dx.doi.org/10.1186/s40814-020-00744-5 |
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