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Comprehensive assessments of germline deletion structural variants reveal the association between prognostic MUC4 and CEP72 deletions and immune response gene expression in colorectal cancer patients

BACKGROUND: Functional disruptions by large germline genomic structural variants in susceptible genes are known risks for cancer. We used deletion structural variants (DSVs) generated from germline whole-genome sequencing (WGS) and DSV immune-related association tumor microenvironment (TME) to predi...

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Detalles Bibliográficos
Autores principales:	Lin, Peng-Chan, Chen, Hui-O, Lee, Chih-Jung, Yeh, Yu-Min, Shen, Meng-Ru, Chiang, Jung-Hsien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802320/ https://www.ncbi.nlm.nih.gov/pubmed/33431054 http://dx.doi.org/10.1186/s40246-020-00302-3

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