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DPPG(2)-Based Thermosensitive Liposomes with Encapsulated Doxorubicin Combined with Hyperthermia Lead to Higher Doxorubicin Concentrations in the Bladder Compared to Conventional Application in Pigs: A Rationale for the Treatment of Muscle-Invasive Bladder Cancer

PURPOSE: Current treatment options for muscle-invasive bladder cancer (MIBC) are associated with substantial morbidity. Local release of doxorubicin (DOX) from phosphatidyldiglycerol-based thermosensitive liposomes (DPPG(2)-TSL-DOX) potentiated by hyperthermia (HT) in the bladder wall may result in...

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Detalles Bibliográficos
Autores principales:	van Valenberg, F Johannes P, Brummelhuis, Iris S G, Lindner, Lars H, Kuhnle, Felix, Wedmann, Barbara, Schweizer, Pascal, Hossann, Martin, Witjes, J Alfred, Oosterwijk, Egbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802347/ https://www.ncbi.nlm.nih.gov/pubmed/33447028 http://dx.doi.org/10.2147/IJN.S280034

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