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The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study

INTRODUCTION: The Quantified behavior Test (QbTest), which combines a continuous performance task (CPT) and motion tracking, provides data for the core signs of attention-deficit/hyperactivity disorder (ADHD): attention, hyperactivity, and impulsivity. This study aimed to evaluate the performance of...

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Autores principales: Knez, Rajna, Stevanovic, Dejan, Nasic, Salmir, Doric, Ana, Wentz, Elisabet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802589/
https://www.ncbi.nlm.nih.gov/pubmed/33447036
http://dx.doi.org/10.2147/NDT.S277490
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author Knez, Rajna
Stevanovic, Dejan
Nasic, Salmir
Doric, Ana
Wentz, Elisabet
author_facet Knez, Rajna
Stevanovic, Dejan
Nasic, Salmir
Doric, Ana
Wentz, Elisabet
author_sort Knez, Rajna
collection PubMed
description INTRODUCTION: The Quantified behavior Test (QbTest), which combines a continuous performance task (CPT) and motion tracking, provides data for the core signs of attention-deficit/hyperactivity disorder (ADHD): attention, hyperactivity, and impulsivity. This study aimed to evaluate the performance of children and adolescents with ADHD on the QbTest before and after a single methylphenidate (MPH) dose. SUBJECTS AND METHODS: This retrospective chart review study included data from 149 children and 215 adolescents who completed the QbTest. A summary index of the CPT and motion capture data on the QbTest is provided by three cardinal parameters: QbActivity, QbImpulsivity, and QbInattention. The test was performed twice on the same day, before and up to three hours after MPH intake. A decrease by ≥ 0.5 in a cardinal parameter score was considered an improvement, whereas an increase by ≥ 0.5 a deterioration. RESULTS: QbActivity improvement after MPH intake was present in 71.7% and 76.2% of the children and adolescents, respectively. QbImpulsivity improvement was observed in 50.4% of the children and 44.7% of the adolescents, and QbInattention improvement in 85.1% and 91.1% of the children and adolescents, respectively. All three parameters improved simultaneously in 27.7% of the children and 28.7% of the adolescents. The likelihood that one parameter deteriorated after MPH use was greater if that parameter was within the normal range before medication. This was most pronounced for QbImpulsivity. Among male adolescents, QbInattention improvement was often accompanied by QbImpulsivity deterioration. CONCLUSION: The QbTest inattention and motor activity parameters improved markedly after a single MPH dose in children and adolescents with ADHD, while less so for impulsivity. Improvement of one parameter is not necessarily associated with improvement of the other two, and deterioration, especially regarding impulsivity, may occur. If confirmed, these results highlight the need for optimization and individualization of MPH treatment, while monitoring all aspects of the ADHD symptomatology based on the QbTest performance.
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spelling pubmed-78025892021-01-13 The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study Knez, Rajna Stevanovic, Dejan Nasic, Salmir Doric, Ana Wentz, Elisabet Neuropsychiatr Dis Treat Original Research INTRODUCTION: The Quantified behavior Test (QbTest), which combines a continuous performance task (CPT) and motion tracking, provides data for the core signs of attention-deficit/hyperactivity disorder (ADHD): attention, hyperactivity, and impulsivity. This study aimed to evaluate the performance of children and adolescents with ADHD on the QbTest before and after a single methylphenidate (MPH) dose. SUBJECTS AND METHODS: This retrospective chart review study included data from 149 children and 215 adolescents who completed the QbTest. A summary index of the CPT and motion capture data on the QbTest is provided by three cardinal parameters: QbActivity, QbImpulsivity, and QbInattention. The test was performed twice on the same day, before and up to three hours after MPH intake. A decrease by ≥ 0.5 in a cardinal parameter score was considered an improvement, whereas an increase by ≥ 0.5 a deterioration. RESULTS: QbActivity improvement after MPH intake was present in 71.7% and 76.2% of the children and adolescents, respectively. QbImpulsivity improvement was observed in 50.4% of the children and 44.7% of the adolescents, and QbInattention improvement in 85.1% and 91.1% of the children and adolescents, respectively. All three parameters improved simultaneously in 27.7% of the children and 28.7% of the adolescents. The likelihood that one parameter deteriorated after MPH use was greater if that parameter was within the normal range before medication. This was most pronounced for QbImpulsivity. Among male adolescents, QbInattention improvement was often accompanied by QbImpulsivity deterioration. CONCLUSION: The QbTest inattention and motor activity parameters improved markedly after a single MPH dose in children and adolescents with ADHD, while less so for impulsivity. Improvement of one parameter is not necessarily associated with improvement of the other two, and deterioration, especially regarding impulsivity, may occur. If confirmed, these results highlight the need for optimization and individualization of MPH treatment, while monitoring all aspects of the ADHD symptomatology based on the QbTest performance. Dove 2021-01-06 /pmc/articles/PMC7802589/ /pubmed/33447036 http://dx.doi.org/10.2147/NDT.S277490 Text en © 2021 Knez et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Knez, Rajna
Stevanovic, Dejan
Nasic, Salmir
Doric, Ana
Wentz, Elisabet
The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study
title The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study
title_full The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study
title_fullStr The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study
title_full_unstemmed The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study
title_short The Impact of Methylphenidate on QbTest Performance of Children with ADHD: A Retrospective Clinical Study
title_sort impact of methylphenidate on qbtest performance of children with adhd: a retrospective clinical study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802589/
https://www.ncbi.nlm.nih.gov/pubmed/33447036
http://dx.doi.org/10.2147/NDT.S277490
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