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Gorham Stout disease: a case report from Syria
Gorham-Stout disease (GSD) is a rare entity that destroys the bone matrix resulting mainly in osteolysis, pain and pathologic fractures among a broader clinical picture. We report a case of a 60-year-old female with a sudden discovery of pathologic fractures in the pelvis and the absence of the left...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802812/ https://www.ncbi.nlm.nih.gov/pubmed/33469472 http://dx.doi.org/10.1093/omcr/omaa121 |
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author | Esper, Asil Alhoulaiby, Sami Emran, Areege Youssef, Safwan Alshehabi, Zuheir |
author_facet | Esper, Asil Alhoulaiby, Sami Emran, Areege Youssef, Safwan Alshehabi, Zuheir |
author_sort | Esper, Asil |
collection | PubMed |
description | Gorham-Stout disease (GSD) is a rare entity that destroys the bone matrix resulting mainly in osteolysis, pain and pathologic fractures among a broader clinical picture. We report a case of a 60-year-old female with a sudden discovery of pathologic fractures in the pelvis and the absence of the left femoral head. On biopsy, no cellular atypia was found, instead disturbed bone formation with prominent vascularity with scattered foci of necrosis & osteolysis, which lead to the diagnosis of GSD. Possible differential diagnoses were discussed and excluded. The patient was put on Bisphosphonate that led to a relative improvement in the symptoms. This disease needs a more thorough investigation to identify the key cause, what is beyond the scope of this report. |
format | Online Article Text |
id | pubmed-7802812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-78028122021-01-18 Gorham Stout disease: a case report from Syria Esper, Asil Alhoulaiby, Sami Emran, Areege Youssef, Safwan Alshehabi, Zuheir Oxf Med Case Reports Case Report Gorham-Stout disease (GSD) is a rare entity that destroys the bone matrix resulting mainly in osteolysis, pain and pathologic fractures among a broader clinical picture. We report a case of a 60-year-old female with a sudden discovery of pathologic fractures in the pelvis and the absence of the left femoral head. On biopsy, no cellular atypia was found, instead disturbed bone formation with prominent vascularity with scattered foci of necrosis & osteolysis, which lead to the diagnosis of GSD. Possible differential diagnoses were discussed and excluded. The patient was put on Bisphosphonate that led to a relative improvement in the symptoms. This disease needs a more thorough investigation to identify the key cause, what is beyond the scope of this report. Oxford University Press 2021-01-12 /pmc/articles/PMC7802812/ /pubmed/33469472 http://dx.doi.org/10.1093/omcr/omaa121 Text en © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Esper, Asil Alhoulaiby, Sami Emran, Areege Youssef, Safwan Alshehabi, Zuheir Gorham Stout disease: a case report from Syria |
title | Gorham Stout disease: a case report from Syria |
title_full | Gorham Stout disease: a case report from Syria |
title_fullStr | Gorham Stout disease: a case report from Syria |
title_full_unstemmed | Gorham Stout disease: a case report from Syria |
title_short | Gorham Stout disease: a case report from Syria |
title_sort | gorham stout disease: a case report from syria |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802812/ https://www.ncbi.nlm.nih.gov/pubmed/33469472 http://dx.doi.org/10.1093/omcr/omaa121 |
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