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SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
Embryonic stem cells provide their major contribution to embryogenesis through formation of germ layers as they have pluripotency potential and capacity for self-renewal. Retention of pluripotency of these stem cells depends on expression/level of transcription factors, i.e., SOX2, OCT4 and NANOG. D...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802841/ https://www.ncbi.nlm.nih.gov/pubmed/33456249 http://dx.doi.org/10.4103/jomfp.JOMFP_22_20 |
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author | Swain, Niharika Thakur, Mansee Pathak, Jigna Swain, Biswaranjan |
author_facet | Swain, Niharika Thakur, Mansee Pathak, Jigna Swain, Biswaranjan |
author_sort | Swain, Niharika |
collection | PubMed |
description | Embryonic stem cells provide their major contribution to embryogenesis through formation of germ layers as they have pluripotency potential and capacity for self-renewal. Retention of pluripotency of these stem cells depends on expression/level of transcription factors, i.e., SOX2, OCT4 and NANOG. During organogenesis, the altered expression of the molecules also influences these stem cells to lose their pluripotency and turn toward the lineage selection. As the differentiation progresses, the maintenance of the somatic cells including the oral squamous cells also depends on differential expression of the transcription factors to some extent. Recently, many experimental and observational studies documented the significant contribution in carcinogenesis of various human cancers. In this review, we have attempted to summarize the evidences indicating about the putative role of these master pluripotency regulators in various phases of oral carcinogenesis i.e. initiation , progression and prognosis of oral squamous cell carcinoma. |
format | Online Article Text |
id | pubmed-7802841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-78028412021-01-15 SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis Swain, Niharika Thakur, Mansee Pathak, Jigna Swain, Biswaranjan J Oral Maxillofac Pathol Review Article Embryonic stem cells provide their major contribution to embryogenesis through formation of germ layers as they have pluripotency potential and capacity for self-renewal. Retention of pluripotency of these stem cells depends on expression/level of transcription factors, i.e., SOX2, OCT4 and NANOG. During organogenesis, the altered expression of the molecules also influences these stem cells to lose their pluripotency and turn toward the lineage selection. As the differentiation progresses, the maintenance of the somatic cells including the oral squamous cells also depends on differential expression of the transcription factors to some extent. Recently, many experimental and observational studies documented the significant contribution in carcinogenesis of various human cancers. In this review, we have attempted to summarize the evidences indicating about the putative role of these master pluripotency regulators in various phases of oral carcinogenesis i.e. initiation , progression and prognosis of oral squamous cell carcinoma. Wolters Kluwer - Medknow 2020 2020-09-09 /pmc/articles/PMC7802841/ /pubmed/33456249 http://dx.doi.org/10.4103/jomfp.JOMFP_22_20 Text en Copyright: © 2020 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Swain, Niharika Thakur, Mansee Pathak, Jigna Swain, Biswaranjan SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis |
title | SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis |
title_full | SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis |
title_fullStr | SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis |
title_full_unstemmed | SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis |
title_short | SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis |
title_sort | sox2, oct4 and nanog: the core embryonic stem cell pluripotency regulators in oral carcinogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802841/ https://www.ncbi.nlm.nih.gov/pubmed/33456249 http://dx.doi.org/10.4103/jomfp.JOMFP_22_20 |
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