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SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis

Embryonic stem cells provide their major contribution to embryogenesis through formation of germ layers as they have pluripotency potential and capacity for self-renewal. Retention of pluripotency of these stem cells depends on expression/level of transcription factors, i.e., SOX2, OCT4 and NANOG. D...

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Autores principales: Swain, Niharika, Thakur, Mansee, Pathak, Jigna, Swain, Biswaranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802841/
https://www.ncbi.nlm.nih.gov/pubmed/33456249
http://dx.doi.org/10.4103/jomfp.JOMFP_22_20
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author Swain, Niharika
Thakur, Mansee
Pathak, Jigna
Swain, Biswaranjan
author_facet Swain, Niharika
Thakur, Mansee
Pathak, Jigna
Swain, Biswaranjan
author_sort Swain, Niharika
collection PubMed
description Embryonic stem cells provide their major contribution to embryogenesis through formation of germ layers as they have pluripotency potential and capacity for self-renewal. Retention of pluripotency of these stem cells depends on expression/level of transcription factors, i.e., SOX2, OCT4 and NANOG. During organogenesis, the altered expression of the molecules also influences these stem cells to lose their pluripotency and turn toward the lineage selection. As the differentiation progresses, the maintenance of the somatic cells including the oral squamous cells also depends on differential expression of the transcription factors to some extent. Recently, many experimental and observational studies documented the significant contribution in carcinogenesis of various human cancers. In this review, we have attempted to summarize the evidences indicating about the putative role of these master pluripotency regulators in various phases of oral carcinogenesis i.e. initiation , progression and prognosis of oral squamous cell carcinoma.
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spelling pubmed-78028412021-01-15 SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis Swain, Niharika Thakur, Mansee Pathak, Jigna Swain, Biswaranjan J Oral Maxillofac Pathol Review Article Embryonic stem cells provide their major contribution to embryogenesis through formation of germ layers as they have pluripotency potential and capacity for self-renewal. Retention of pluripotency of these stem cells depends on expression/level of transcription factors, i.e., SOX2, OCT4 and NANOG. During organogenesis, the altered expression of the molecules also influences these stem cells to lose their pluripotency and turn toward the lineage selection. As the differentiation progresses, the maintenance of the somatic cells including the oral squamous cells also depends on differential expression of the transcription factors to some extent. Recently, many experimental and observational studies documented the significant contribution in carcinogenesis of various human cancers. In this review, we have attempted to summarize the evidences indicating about the putative role of these master pluripotency regulators in various phases of oral carcinogenesis i.e. initiation , progression and prognosis of oral squamous cell carcinoma. Wolters Kluwer - Medknow 2020 2020-09-09 /pmc/articles/PMC7802841/ /pubmed/33456249 http://dx.doi.org/10.4103/jomfp.JOMFP_22_20 Text en Copyright: © 2020 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Swain, Niharika
Thakur, Mansee
Pathak, Jigna
Swain, Biswaranjan
SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
title SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
title_full SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
title_fullStr SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
title_full_unstemmed SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
title_short SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
title_sort sox2, oct4 and nanog: the core embryonic stem cell pluripotency regulators in oral carcinogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802841/
https://www.ncbi.nlm.nih.gov/pubmed/33456249
http://dx.doi.org/10.4103/jomfp.JOMFP_22_20
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