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Oral microbiome and oral cancer – The probable nexus

Oral squamous cell carcinoma is one of the most common malignancies and is the leading cause of morbidity and mortality. The known risk factors for oral cancer are tobacco, alcohol consumption and betel quid chewing. Nutritional deficiencies and certain microorganisms are also associated with oral c...

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Autores principales: Deo, Priya Nimish, Deshmukh, Revati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802843/
https://www.ncbi.nlm.nih.gov/pubmed/33456248
http://dx.doi.org/10.4103/jomfp.JOMFP_20_20
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author Deo, Priya Nimish
Deshmukh, Revati
author_facet Deo, Priya Nimish
Deshmukh, Revati
author_sort Deo, Priya Nimish
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description Oral squamous cell carcinoma is one of the most common malignancies and is the leading cause of morbidity and mortality. The known risk factors for oral cancer are tobacco, alcohol consumption and betel quid chewing. Nutritional deficiencies and certain microorganisms are also associated with oral cancer. Oral cavity is a host to numerous microorganisms, majority of which are bacterial communities along with fungi and viruses. A possibility of the dysregulation of the oral microbiome cannot be ignored. Oral microbiome is defined as the collective genome of microorganisms that reside in the oral cavity. With the development of culture-independent techniques, the detection and identification of the bacteria which cannot be cultured has become possible. Revolution in technology has led to increased research in this area in an attempt to find the role of microbiome in health and disease. Before identifying the exact role the microbiome plays in the development of oral cancer, it is essential to profile the microbiome in healthy individuals and patients with oral cancer. It is essential to note that oral cancer may sometimes occur without any habit too!! This article is an attempt to review the role of oral microbiome in oral cancer with a focus on the bacteriome, its related studies and in brief about the omics technologies in understanding the microbiome.
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spelling pubmed-78028432021-01-15 Oral microbiome and oral cancer – The probable nexus Deo, Priya Nimish Deshmukh, Revati J Oral Maxillofac Pathol Review Article Oral squamous cell carcinoma is one of the most common malignancies and is the leading cause of morbidity and mortality. The known risk factors for oral cancer are tobacco, alcohol consumption and betel quid chewing. Nutritional deficiencies and certain microorganisms are also associated with oral cancer. Oral cavity is a host to numerous microorganisms, majority of which are bacterial communities along with fungi and viruses. A possibility of the dysregulation of the oral microbiome cannot be ignored. Oral microbiome is defined as the collective genome of microorganisms that reside in the oral cavity. With the development of culture-independent techniques, the detection and identification of the bacteria which cannot be cultured has become possible. Revolution in technology has led to increased research in this area in an attempt to find the role of microbiome in health and disease. Before identifying the exact role the microbiome plays in the development of oral cancer, it is essential to profile the microbiome in healthy individuals and patients with oral cancer. It is essential to note that oral cancer may sometimes occur without any habit too!! This article is an attempt to review the role of oral microbiome in oral cancer with a focus on the bacteriome, its related studies and in brief about the omics technologies in understanding the microbiome. Wolters Kluwer - Medknow 2020 2020-09-09 /pmc/articles/PMC7802843/ /pubmed/33456248 http://dx.doi.org/10.4103/jomfp.JOMFP_20_20 Text en Copyright: © 2020 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Deo, Priya Nimish
Deshmukh, Revati
Oral microbiome and oral cancer – The probable nexus
title Oral microbiome and oral cancer – The probable nexus
title_full Oral microbiome and oral cancer – The probable nexus
title_fullStr Oral microbiome and oral cancer – The probable nexus
title_full_unstemmed Oral microbiome and oral cancer – The probable nexus
title_short Oral microbiome and oral cancer – The probable nexus
title_sort oral microbiome and oral cancer – the probable nexus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802843/
https://www.ncbi.nlm.nih.gov/pubmed/33456248
http://dx.doi.org/10.4103/jomfp.JOMFP_20_20
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