Cargando…

Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma

BACKGROUND: The Immunomorphological patterns of Lymph Nodes indirectly assess the host immune response facing a malignant tumor. These patterns also help us predict the susceptibility of the patient to Lymph Node Metastasis. AIMS AND OBJECTIVES: To evaluate the Immunomorphological patterns of Lymph...

Descripción completa

Detalles Bibliográficos
Autores principales: Balla, Hyandavi, Uppala, Divya, Majumdar, Sumit, Kotina, Sreekanth, Kodati, Sravya, Namana, Madhurya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802857/
https://www.ncbi.nlm.nih.gov/pubmed/33456238
http://dx.doi.org/10.4103/jomfp.JOMFP_36_18
_version_ 1783635827442581504
author Balla, Hyandavi
Uppala, Divya
Majumdar, Sumit
Kotina, Sreekanth
Kodati, Sravya
Namana, Madhurya
author_facet Balla, Hyandavi
Uppala, Divya
Majumdar, Sumit
Kotina, Sreekanth
Kodati, Sravya
Namana, Madhurya
author_sort Balla, Hyandavi
collection PubMed
description BACKGROUND: The Immunomorphological patterns of Lymph Nodes indirectly assess the host immune response facing a malignant tumor. These patterns also help us predict the susceptibility of the patient to Lymph Node Metastasis. AIMS AND OBJECTIVES: To evaluate the Immunomorphological patterns of Lymph Nodes in Oral Squamous Cell Carcinoma and to correlate them with the histopathological subtype of Oral Squamous Cell Carcinoma, TNM staging and the degree of tumor involvement within the Lymph Nodes. METHODOLOGY: A total of 40 subjects were taken for the study. Individuals who were clinically and histopathologically diagnosed as cases of Squamous Cell Carcinoma, who had undergone Radical or Elective Neck dissection were considered. The excised Lymph Nodes along with the primary tumor were collected stained with Hematoxylin and Eosin. The Lymph Nodes were assessed for Metastasis and Immunomorphological patterns. Statistical Correlation was done between the Immunomorphological pattern of Lymph Nodes and (a) Size of the tumor, (b) TNM stage of the tumor, (c) Histopathological Grade of the primary tumor, (d) Metastasis of the Lymph Node and (e) Grade of the Metastasis of Lymph Node. Statistical Correlation was done between the Metastasis of the Lymph Node and (a) Size of the tumor and (b) TNM stage of the tumor. RESULTS AND CONCLUSION: Statistically, a significant association was observed between TNM staging and Immunomorphological patterns of Lymph Node (P < 0.01). The relationship between histopathological grade of primary tumor of Squamous Cell Carcinoma and the Immunomorphological patterns was statistically significant (P < 0.01). Statistically, a significant association was observed between Sinus Histiocytosis pattern and decreased occurrence of nodal metastasis (P < 0.01).
format Online
Article
Text
id pubmed-7802857
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-78028572021-01-15 Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma Balla, Hyandavi Uppala, Divya Majumdar, Sumit Kotina, Sreekanth Kodati, Sravya Namana, Madhurya J Oral Maxillofac Pathol Original Article BACKGROUND: The Immunomorphological patterns of Lymph Nodes indirectly assess the host immune response facing a malignant tumor. These patterns also help us predict the susceptibility of the patient to Lymph Node Metastasis. AIMS AND OBJECTIVES: To evaluate the Immunomorphological patterns of Lymph Nodes in Oral Squamous Cell Carcinoma and to correlate them with the histopathological subtype of Oral Squamous Cell Carcinoma, TNM staging and the degree of tumor involvement within the Lymph Nodes. METHODOLOGY: A total of 40 subjects were taken for the study. Individuals who were clinically and histopathologically diagnosed as cases of Squamous Cell Carcinoma, who had undergone Radical or Elective Neck dissection were considered. The excised Lymph Nodes along with the primary tumor were collected stained with Hematoxylin and Eosin. The Lymph Nodes were assessed for Metastasis and Immunomorphological patterns. Statistical Correlation was done between the Immunomorphological pattern of Lymph Nodes and (a) Size of the tumor, (b) TNM stage of the tumor, (c) Histopathological Grade of the primary tumor, (d) Metastasis of the Lymph Node and (e) Grade of the Metastasis of Lymph Node. Statistical Correlation was done between the Metastasis of the Lymph Node and (a) Size of the tumor and (b) TNM stage of the tumor. RESULTS AND CONCLUSION: Statistically, a significant association was observed between TNM staging and Immunomorphological patterns of Lymph Node (P < 0.01). The relationship between histopathological grade of primary tumor of Squamous Cell Carcinoma and the Immunomorphological patterns was statistically significant (P < 0.01). Statistically, a significant association was observed between Sinus Histiocytosis pattern and decreased occurrence of nodal metastasis (P < 0.01). Wolters Kluwer - Medknow 2020 2020-09-09 /pmc/articles/PMC7802857/ /pubmed/33456238 http://dx.doi.org/10.4103/jomfp.JOMFP_36_18 Text en Copyright: © 2020 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Balla, Hyandavi
Uppala, Divya
Majumdar, Sumit
Kotina, Sreekanth
Kodati, Sravya
Namana, Madhurya
Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma
title Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma
title_full Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma
title_fullStr Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma
title_full_unstemmed Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma
title_short Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma
title_sort evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802857/
https://www.ncbi.nlm.nih.gov/pubmed/33456238
http://dx.doi.org/10.4103/jomfp.JOMFP_36_18
work_keys_str_mv AT ballahyandavi evaluationofimmunomorphologicalpatternsofcervicallymphnodesinoralsquamouscellcarcinoma
AT uppaladivya evaluationofimmunomorphologicalpatternsofcervicallymphnodesinoralsquamouscellcarcinoma
AT majumdarsumit evaluationofimmunomorphologicalpatternsofcervicallymphnodesinoralsquamouscellcarcinoma
AT kotinasreekanth evaluationofimmunomorphologicalpatternsofcervicallymphnodesinoralsquamouscellcarcinoma
AT kodatisravya evaluationofimmunomorphologicalpatternsofcervicallymphnodesinoralsquamouscellcarcinoma
AT namanamadhurya evaluationofimmunomorphologicalpatternsofcervicallymphnodesinoralsquamouscellcarcinoma