A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines

Coronavirus disease-2019 (COVID-19) has become a major global epidemic. Facilitated by HTS(2) technology, we evaluated the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on cytokine storm-related signaling pathways, and identified the key targets of the relevant pathways and po...

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Detalles Bibliográficos
Autores principales: Dai, Yifei, Qiang, Weijie, Gui, Yu, Tan, Xue, Pei, Tianli, Lin, Kequan, Cai, Siwei, Sun, Liang, Ning, Guochen, Wang, Jianxun, Guo, Hongyan, Sun, Yimin, Cheng, Jing, Xie, Lan, Lan, Xun, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science China Press. Published by Elsevier B.V. and Science China Press. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803147/
https://www.ncbi.nlm.nih.gov/pubmed/33457042
http://dx.doi.org/10.1016/j.scib.2021.01.005
Descripción
Sumario:Coronavirus disease-2019 (COVID-19) has become a major global epidemic. Facilitated by HTS(2) technology, we evaluated the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on cytokine storm-related signaling pathways, and identified the key targets of the relevant pathways and potential active ingredients in these herbs. This large-scale transcriptional study innovatively combines HTS(2) technology with bioinformatics methods and computer-aided drug design. For the first time, it systematically explores the molecular mechanism of TCM in regulating the COVID-19-related cytokine storm, providing an important scientific basis for elucidating the mechanism of action of TCM in treating COVID-19. [Figure: see text]

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