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In Silico Prediction of the Mode of Action of Viola odorata in Diabetes
BACKGROUND: The metabolic syndrome increases the risk of different diseases such as type 2 diabetes. The prevalence of metabolic syndrome has rapidly grown and affected more than 230 million people worldwide. Viola odorata is a traditionally used plant for the treatment of diabetes; however, its mec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803256/ https://www.ncbi.nlm.nih.gov/pubmed/33490239 http://dx.doi.org/10.1155/2020/2768403 |
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author | Buabeid, Manal Ali Arafa, El-Shaimaa A. Hassan, Waseem Murtaza, Ghulam |
author_facet | Buabeid, Manal Ali Arafa, El-Shaimaa A. Hassan, Waseem Murtaza, Ghulam |
author_sort | Buabeid, Manal Ali |
collection | PubMed |
description | BACKGROUND: The metabolic syndrome increases the risk of different diseases such as type 2 diabetes. The prevalence of metabolic syndrome has rapidly grown and affected more than 230 million people worldwide. Viola odorata is a traditionally used plant for the treatment of diabetes; however, its mechanism to manage diabetes is still unknown. PURPOSE: This study was designed to systematically assess the mechanism of action of Viola odorata in diabetes. METHODS: An extensive literature search was made to establish an ingredient-target database of Viola odorata. Of these, targets related to diabetes were identified and used to develop a protein-protein interaction network (PPIN) by utilizing the STITCH database. The obtained PPIN was assessed through Gene Ontology (GO) enrichment analysis based on ClueGO plugin. RESULTS: According to the acquired data, there were about 143 chemical constituents present in Viola odorata having 119 protein targets. Of these, 31 targets were established to give the pharmacological effect against diabetes. The UniProt database was used for screening of 31 targets, out of which Homo sapiens contained 22 targets. Ultimately, 207 GO terms, grouped into 41 clusters, were found by gene analysis, and most of them were found to be linked with diabetes. According to findings, several proteins including TP53, BCL2, CDKN1A, 1L6, CCND1, CDKN2A, and RB1 have a significant role in the treatment of diabetes by Viola odorata. CONCLUSION: The possible activity of Viola odorata in the management of diabetes may be mediated by several molecular mechanisms, including the glutamine metabolic process, IRE1-mediated unfolded protein response, and pentose metabolic process. |
format | Online Article Text |
id | pubmed-7803256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-78032562021-01-22 In Silico Prediction of the Mode of Action of Viola odorata in Diabetes Buabeid, Manal Ali Arafa, El-Shaimaa A. Hassan, Waseem Murtaza, Ghulam Biomed Res Int Research Article BACKGROUND: The metabolic syndrome increases the risk of different diseases such as type 2 diabetes. The prevalence of metabolic syndrome has rapidly grown and affected more than 230 million people worldwide. Viola odorata is a traditionally used plant for the treatment of diabetes; however, its mechanism to manage diabetes is still unknown. PURPOSE: This study was designed to systematically assess the mechanism of action of Viola odorata in diabetes. METHODS: An extensive literature search was made to establish an ingredient-target database of Viola odorata. Of these, targets related to diabetes were identified and used to develop a protein-protein interaction network (PPIN) by utilizing the STITCH database. The obtained PPIN was assessed through Gene Ontology (GO) enrichment analysis based on ClueGO plugin. RESULTS: According to the acquired data, there were about 143 chemical constituents present in Viola odorata having 119 protein targets. Of these, 31 targets were established to give the pharmacological effect against diabetes. The UniProt database was used for screening of 31 targets, out of which Homo sapiens contained 22 targets. Ultimately, 207 GO terms, grouped into 41 clusters, were found by gene analysis, and most of them were found to be linked with diabetes. According to findings, several proteins including TP53, BCL2, CDKN1A, 1L6, CCND1, CDKN2A, and RB1 have a significant role in the treatment of diabetes by Viola odorata. CONCLUSION: The possible activity of Viola odorata in the management of diabetes may be mediated by several molecular mechanisms, including the glutamine metabolic process, IRE1-mediated unfolded protein response, and pentose metabolic process. Hindawi 2020-10-31 /pmc/articles/PMC7803256/ /pubmed/33490239 http://dx.doi.org/10.1155/2020/2768403 Text en Copyright © 2020 Manal Ali Buabeid et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Buabeid, Manal Ali Arafa, El-Shaimaa A. Hassan, Waseem Murtaza, Ghulam In Silico Prediction of the Mode of Action of Viola odorata in Diabetes |
title |
In Silico Prediction of the Mode of Action of Viola odorata in Diabetes |
title_full |
In Silico Prediction of the Mode of Action of Viola odorata in Diabetes |
title_fullStr |
In Silico Prediction of the Mode of Action of Viola odorata in Diabetes |
title_full_unstemmed |
In Silico Prediction of the Mode of Action of Viola odorata in Diabetes |
title_short |
In Silico Prediction of the Mode of Action of Viola odorata in Diabetes |
title_sort | in silico prediction of the mode of action of viola odorata in diabetes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803256/ https://www.ncbi.nlm.nih.gov/pubmed/33490239 http://dx.doi.org/10.1155/2020/2768403 |
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