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Glucocorticoids and Trabecular Bone Score
TBS (Trabecular Bone Score) is the latest tool for clinicians to evaluate bone micro-architecture based on a pixel greyscale, which is provided by lumbar dual-energy X-ray absorptiometry (DXA). Its use enhances fracture prediction in addition to DXA-BMD (Bone Mineral Density). This is independent of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803323/ https://www.ncbi.nlm.nih.gov/pubmed/33456590 http://dx.doi.org/10.25122/jml-2019-0131 |
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author | Sandru, Florica Carsote, Mara Dumitrascu, Mihai Cristian Albu, Simona Elena Valea, Ana |
author_facet | Sandru, Florica Carsote, Mara Dumitrascu, Mihai Cristian Albu, Simona Elena Valea, Ana |
author_sort | Sandru, Florica |
collection | PubMed |
description | TBS (Trabecular Bone Score) is the latest tool for clinicians to evaluate bone micro-architecture based on a pixel greyscale, which is provided by lumbar dual-energy X-ray absorptiometry (DXA). Its use enhances fracture prediction in addition to DXA-BMD (Bone Mineral Density). This is independent of fracture risk assessment (FRAX) and DXA results. We present a narrative review regarding the connection between TBS and Glucocorticoids (GC), either as a drug used for different conditions or as a tumor-produced endogenous excess. TBS is a better discriminator for GC-induced vertebral fractures compared to DXA-BMD. This aspect is similarly available for patients with osteoporosis diagnosed by DXA. TBS is inversely correlated with the cumulative dose of GC (systemic or inhaled), with disease duration, and positively correlated with respiratory function in patients with asthma. Low TBS values are found in females with a T-score at the hip within the osteoporosis range, with diabetes mellitus, or who use GC. Lumbar TBS is a screening tool in menopausal women with type 2 diabetes mellitus. TBS is an independent parameter that provides information regarding skeleton deterioration in diabetic patients receiving GC therapy in a manner complementary to DXA-BMD. TBS might become an essential step regarding the adrenalectomy decision in patients with adrenal incidentaloma in whom autonomous cortisol secretion might damage bone micro-architecture. TBS currently represents a standard tool of fracture risk evaluation in patients receiving GC therapy or with endogenous Cushing’s syndrome, a tool easy to be applied by different practitioners since GCs are largely used |
format | Online Article Text |
id | pubmed-7803323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-78033232021-01-15 Glucocorticoids and Trabecular Bone Score Sandru, Florica Carsote, Mara Dumitrascu, Mihai Cristian Albu, Simona Elena Valea, Ana J Med Life Original Article TBS (Trabecular Bone Score) is the latest tool for clinicians to evaluate bone micro-architecture based on a pixel greyscale, which is provided by lumbar dual-energy X-ray absorptiometry (DXA). Its use enhances fracture prediction in addition to DXA-BMD (Bone Mineral Density). This is independent of fracture risk assessment (FRAX) and DXA results. We present a narrative review regarding the connection between TBS and Glucocorticoids (GC), either as a drug used for different conditions or as a tumor-produced endogenous excess. TBS is a better discriminator for GC-induced vertebral fractures compared to DXA-BMD. This aspect is similarly available for patients with osteoporosis diagnosed by DXA. TBS is inversely correlated with the cumulative dose of GC (systemic or inhaled), with disease duration, and positively correlated with respiratory function in patients with asthma. Low TBS values are found in females with a T-score at the hip within the osteoporosis range, with diabetes mellitus, or who use GC. Lumbar TBS is a screening tool in menopausal women with type 2 diabetes mellitus. TBS is an independent parameter that provides information regarding skeleton deterioration in diabetic patients receiving GC therapy in a manner complementary to DXA-BMD. TBS might become an essential step regarding the adrenalectomy decision in patients with adrenal incidentaloma in whom autonomous cortisol secretion might damage bone micro-architecture. TBS currently represents a standard tool of fracture risk evaluation in patients receiving GC therapy or with endogenous Cushing’s syndrome, a tool easy to be applied by different practitioners since GCs are largely used Carol Davila University Press 2020 /pmc/articles/PMC7803323/ /pubmed/33456590 http://dx.doi.org/10.25122/jml-2019-0131 Text en ©Carol Davila University Press This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Sandru, Florica Carsote, Mara Dumitrascu, Mihai Cristian Albu, Simona Elena Valea, Ana Glucocorticoids and Trabecular Bone Score |
title | Glucocorticoids and Trabecular Bone Score |
title_full | Glucocorticoids and Trabecular Bone Score |
title_fullStr | Glucocorticoids and Trabecular Bone Score |
title_full_unstemmed | Glucocorticoids and Trabecular Bone Score |
title_short | Glucocorticoids and Trabecular Bone Score |
title_sort | glucocorticoids and trabecular bone score |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803323/ https://www.ncbi.nlm.nih.gov/pubmed/33456590 http://dx.doi.org/10.25122/jml-2019-0131 |
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