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Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children

The study aimed to identify certain factors related to family history, pathological conditions, or exposure-type that are significantly correlated with recurrent wheezing and/or asthma in children. One hundred nine children with recurrent wheezing and 44 children with asthma were studied in order to...

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Autores principales: Bogdan, Raluca Daniela, Rusu, Lidia, Toma, Adrian Ioan, Nastase, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803326/
https://www.ncbi.nlm.nih.gov/pubmed/33456612
http://dx.doi.org/10.25122/jml-2020-0143
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author Bogdan, Raluca Daniela
Rusu, Lidia
Toma, Adrian Ioan
Nastase, Leonard
author_facet Bogdan, Raluca Daniela
Rusu, Lidia
Toma, Adrian Ioan
Nastase, Leonard
author_sort Bogdan, Raluca Daniela
collection PubMed
description The study aimed to identify certain factors related to family history, pathological conditions, or exposure-type that are significantly correlated with recurrent wheezing and/or asthma in children. One hundred nine children with recurrent wheezing and 44 children with asthma were studied in order to identify the degree of correlation of these conditions with familial history of asthma or atopy, child’s age group, gender, premature birth, perinatal asphyxia, neonatal infection, and antibiotic treatment during the neonatal period, history of atopy and obesity and histamine intolerance, nasopharyngeal bacterial colonization, pneumonia with bronchospasm. The clinical picture of these two diseases was also compared regarding the severity of exacerbations and their response to controller therapy. The medium age of children diagnosed with recurrent wheezing was significantly lower than those diagnosed with asthma (5.64 vs. 9.01 years; p<0.001). Inside the recurrent wheezing group, age distribution differed significantly from the asthma group (p-value <0.001). Atopy was the only pathological condition significantly associated with asthma (56.0%) when compared with the recurrent wheezing group (30.2%) with a relative risk value of 1.34 (p<0.004). For patients colonized with Staphylococcus aureus, the medium number of wheezing exacerbations was significantly higher (p<0.049). Approximately 91% of patients in the recurrent wheezing group and 71% from the asthma group responded to appropriate controller treatment. Our study showed a significant association between asthma and atopy, justifying the need to monitor asthma risk in a child with wheezing and atopy. Nasal carriage of Staphylococcus aureus proved to be significantly associated with the recurrence of wheezing in children.
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spelling pubmed-78033262021-01-15 Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children Bogdan, Raluca Daniela Rusu, Lidia Toma, Adrian Ioan Nastase, Leonard J Med Life Original Article The study aimed to identify certain factors related to family history, pathological conditions, or exposure-type that are significantly correlated with recurrent wheezing and/or asthma in children. One hundred nine children with recurrent wheezing and 44 children with asthma were studied in order to identify the degree of correlation of these conditions with familial history of asthma or atopy, child’s age group, gender, premature birth, perinatal asphyxia, neonatal infection, and antibiotic treatment during the neonatal period, history of atopy and obesity and histamine intolerance, nasopharyngeal bacterial colonization, pneumonia with bronchospasm. The clinical picture of these two diseases was also compared regarding the severity of exacerbations and their response to controller therapy. The medium age of children diagnosed with recurrent wheezing was significantly lower than those diagnosed with asthma (5.64 vs. 9.01 years; p<0.001). Inside the recurrent wheezing group, age distribution differed significantly from the asthma group (p-value <0.001). Atopy was the only pathological condition significantly associated with asthma (56.0%) when compared with the recurrent wheezing group (30.2%) with a relative risk value of 1.34 (p<0.004). For patients colonized with Staphylococcus aureus, the medium number of wheezing exacerbations was significantly higher (p<0.049). Approximately 91% of patients in the recurrent wheezing group and 71% from the asthma group responded to appropriate controller treatment. Our study showed a significant association between asthma and atopy, justifying the need to monitor asthma risk in a child with wheezing and atopy. Nasal carriage of Staphylococcus aureus proved to be significantly associated with the recurrence of wheezing in children. Carol Davila University Press 2020 /pmc/articles/PMC7803326/ /pubmed/33456612 http://dx.doi.org/10.25122/jml-2020-0143 Text en ©Carol Davila University Press This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Bogdan, Raluca Daniela
Rusu, Lidia
Toma, Adrian Ioan
Nastase, Leonard
Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children
title Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children
title_full Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children
title_fullStr Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children
title_full_unstemmed Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children
title_short Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children
title_sort significant clinical associations between exposure type factors and recurrent wheezing and asthma in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803326/
https://www.ncbi.nlm.nih.gov/pubmed/33456612
http://dx.doi.org/10.25122/jml-2020-0143
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