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The Ercc1(-/Δ) mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions
Progeroid murine models represent an emerging tool to investigate mechanisms of aging in an expedient and efficient manner. One prominent mechanism of aging is the accumulation of DNA damage and subsequent increase in cellular senescence, leading to age related pathologies. Ercc1(-/Δ) hypomorphic mi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803498/ https://www.ncbi.nlm.nih.gov/pubmed/33353886 http://dx.doi.org/10.18632/aging.202321 |