Cargando…

6-Bromoindirubin-3’-oxime (6BIO) prevents myocardium from aging by inducing autophagy

6-Bromoindirubin-3’-oxime (6BIO) is a novel small molecule that exerts positive effects on several age-related alterations. However, the anti-aging effects of 6BIO on the aging heart remain unknown. Herein, we aim to investigate the effects of 6BIO on the myocardium and its underlying mechanism in v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Donghao, Cheng, Lizhen, Shen, Yun, Li, Wei, Li, Qinjie, Zhong, Yuan, Miao, Ya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803501/ https://www.ncbi.nlm.nih.gov/pubmed/33401248 http://dx.doi.org/10.18632/aging.202253

Ejemplares similares

6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
por: Guo, Donghao, et al.
Publicado: (2019)

BIO (6-bromoindirubin-3′-oxime) GSK3 inhibitor induces dopaminergic differentiation of human immortalized RenVm cells
por: Soleimani, Mitra, et al.
Publicado: (2018)

Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3′-oxime (7BIO)
por: Broecker-Preuss, Martina, et al.
Publicado: (2015)

The Indirubin Derivative 6-Bromoindirubin-3′-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects
por: Tsakiri, Eleni N., et al.
Publicado: (2017)

6-Bromoindirubin-3′-Oxime Regulates Colony Formation, Apoptosis, and Odonto/Osteogenic Differentiation in Human Dental Pulp Stem Cells
por: Kornsuthisopon, Chatvadee, et al.
Publicado: (2022)

Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice
por: Chen, Liping, et al.
Publicado: (2017)

GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3′-oxime inhibit microRNA maturation in mouse embryonic stem cells
por: Wu, Yongyan, et al.
Publicado: (2015)

Upregulation of flavin-containing monooxygenase 3 mimics calorie restriction to retard liver aging by inducing autophagy
por: Guo, Donghao, et al.
Publicado: (2020)

6-Bromoindirubin-3′-oxime intercepts GSK3 signaling to promote and enhance skeletal muscle differentiation affecting miR-206 expression in mice
por: Ragozzino, Elvira, et al.
Publicado: (2019)

Drug delivery of 6-bromoindirubin-3’-glycerol-oxime ether employing poly(d,l-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solvents
por: Czapka, Anna, et al.
Publicado: (2022)

Publisher Correction: 6-Bromoindirubin-3′-oxime intercepts GSK3 signaling to promote and enhance skeletal muscle differentiation affecting miR-206 expression in mice
por: Ragozzino, Elvira, et al.
Publicado: (2020)

PPRX-1701, a nanoparticle formulation of 6′-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models
por: Zdioruk, Mykola, et al.
Publicado: (2023)

2,6-Dichlorobenzaldehyde oxime
por: Bao, Feng-Yu
Publicado: (2008)

2,6,6-Trimethylcyclohexene-1-carbaldehyde oxime
por: Parthasarathy, Rajasekaran, et al.
Publicado: (2011)

mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer's disease-like pathology in diabetic encephalopathy
por: Cheng, Lizhen, et al.
Publicado: (2023)

Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis
por: Kirpotina, Liliya N., et al.
Publicado: (2020)

Benzamide oxime
por: Xu, Shu-Qing, et al.
Publicado: (2008)

Oximes
por: Cannon, Gillian
Publicado: (2020)

Detection of homing-in of stem cells labeled with technetium-99m hexamethylpropyleneamine oxime in infarcted myocardium after intracoronary injection
por: Patel, Chetan D, et al.
Publicado: (2014)

Experimental and Computational Investigation of the Oxime Bond Stereochemistry in c-Jun N-terminal Kinase 3 Inhibitors 11H-Indeno[1,2-b]quinoxalin-11-one Oxime and Tryptanthrin-6-oxime
por: Matveevskaya, Vladislava V., et al.
Publicado: (2023)

6-bromo-indirubin-3′-oxime (6BIO), a Glycogen synthase kinase-3β inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence-mediated biomolecular damage in human fibroblasts
por: Sklirou, Aimilia D., et al.
Publicado: (2017)

Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia
por: Plotnikov, Mark B., et al.
Publicado: (2023)

Synthesis and In Vitro Antitumor Activity of Naringenin Oxime and Oxime Ether Derivatives
por: Latif, Ahmed Dhahir, et al.
Publicado: (2019)

BioCoder #6
por: O'Reilly Media, Inc
Publicado: (2015)

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
por: Suresh, S. N., et al.
Publicado: (2017)

Aliskiren-attenuated myocardium apoptosis via regulation of autophagy and connexin-43 in aged spontaneously hypertensive rats
por: Zhang, Wenbin, et al.
Publicado: (2014)

A New Route to α-Carbolines Based on 6π-Electrocyclization of Indole-3-alkenyl Oximes
por: Markey, Sophie J., et al.
Publicado: (2013)

Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans
por: Chen, He‐Ping, et al.
Publicado: (2016)

A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling
por: Liu, Lucy, et al.
Publicado: (2012)

Crystal structures of (E)-1-naphthaldehyde oxime and (E)-phenanthrene-9-carbaldehyde oxime
por: Lasri, Jamal, et al.
Publicado: (2018)

(1E)-6-Methoxy-3,4-dihydronaphthalen-1(2H)-one oxime
por: Jin, Da-Cheng, et al.
Publicado: (2010)

Design, Synthesis and Evaluation of Novel Isoxazolines/Oxime Sulfonates of 2′(2′,6′)-(Di)Chloropodophyllotoxins as Insecticidal Agents
por: Yu, Mingqiao, et al.
Publicado: (2016)

Fluoren-9-one oxime
por: Bugenhagen, Bernhard, et al.
Publicado: (2014)

Vegfa Impacts Early Myocardium Development in Zebrafish
por: Zhu, Diqi, et al.
Publicado: (2017)

t-3-Benzyl-r-2,c-6-bis(4-methoxyphenyl)piperidin-4-one oxime
por: Jayabharathi, J., et al.
Publicado: (2008)

1-(1-Benzofuran-2-yl)ethanone O-(2,6-difluorobenzyl)oxime
por: Kosmalski, Tomasz, et al.
Publicado: (2013)

(E)-3-Isopropyl-1-methyl-2,6-diphenylpiperidin-4-one O-nicotinoyl oxime
por: Vinuchakkaravarthy, T., et al.
Publicado: (2014)

Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel
por: Fujita, Masaki, et al.
Publicado: (2021)

(E)-2-Bromobenzaldehyde oxime
por: Zonouzi, Afsaneh, et al.
Publicado: (2011)

(E)-4-Nitrobenzaldehyde oxime
por: Abbas, Asghar, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_pot5rhleedpd2f2j1kfo01vhgh