Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19

Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction open...

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Detalles Bibliográficos
Autores principales: Omarjee, Loukman, Perrot, Frédérique, Meilhac, Olivier, Mahe, Guillaume, Bousquet, Guilhem, Janin, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803547/
https://www.ncbi.nlm.nih.gov/pubmed/33361522
http://dx.doi.org/10.18632/aging.202422
Descripción
Sumario:Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.

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