Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19

Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction open...

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Autores principales: Omarjee, Loukman, Perrot, Frédérique, Meilhac, Olivier, Mahe, Guillaume, Bousquet, Guilhem, Janin, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803547/
https://www.ncbi.nlm.nih.gov/pubmed/33361522
http://dx.doi.org/10.18632/aging.202422
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author Omarjee, Loukman
Perrot, Frédérique
Meilhac, Olivier
Mahe, Guillaume
Bousquet, Guilhem
Janin, Anne
author_facet Omarjee, Loukman
Perrot, Frédérique
Meilhac, Olivier
Mahe, Guillaume
Bousquet, Guilhem
Janin, Anne
author_sort Omarjee, Loukman
collection PubMed
description Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
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spelling pubmed-78035472021-01-15 Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19 Omarjee, Loukman Perrot, Frédérique Meilhac, Olivier Mahe, Guillaume Bousquet, Guilhem Janin, Anne Aging (Albany NY) Review Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease. Impact Journals 2020-12-27 /pmc/articles/PMC7803547/ /pubmed/33361522 http://dx.doi.org/10.18632/aging.202422 Text en Copyright: © 2020 Omarjee et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Omarjee, Loukman
Perrot, Frédérique
Meilhac, Olivier
Mahe, Guillaume
Bousquet, Guilhem
Janin, Anne
Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
title Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
title_full Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
title_fullStr Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
title_full_unstemmed Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
title_short Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
title_sort immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803547/
https://www.ncbi.nlm.nih.gov/pubmed/33361522
http://dx.doi.org/10.18632/aging.202422
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