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δ-opioid receptor activation protects against Parkinson’s disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy
Our previous studies have shown that the δ-opioid receptor (DOR) is an important neuroprotector via the regulation of PTEN-induced kinase 1 (PINK1), a mitochondria-related molecule, under hypoxic and MPP(+) insults. Since mitochondrial dysfunctions are observed in both hypoxia and MPP(+) insults, th...
Autores principales: | Xu, Yuan, Zhi, Feng, Mao, Jiahao, Peng, Ya, Shao, Naiyuan, Balboni, Gianfranco, Yang, Yilin, Xia, Ying |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803568/ https://www.ncbi.nlm.nih.gov/pubmed/33197884 http://dx.doi.org/10.18632/aging.103970 |
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