Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues

Species differences in hepatic metabolism of thyroxine (T4) by uridine diphosphate glucuronosyl transferase (UGT) and susceptibility to thyroid hormone imbalance could underlie differences in thyroid carcinogenesis caused by hepatic enzyme inducers in rats and humans. To investigate this hypothesis...

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Detalles Bibliográficos
Autores principales: Plummer, Simon, Beaumont, Bobby, Elcombe, Matthew, Wallace, Stephanie, Wright, Jayne, Mcinnes, Elizabeth F, Currie, Richard A, Cowie, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803626/
https://www.ncbi.nlm.nih.gov/pubmed/33473352
http://dx.doi.org/10.1016/j.toxrep.2020.12.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803626/
https://www.ncbi.nlm.nih.gov/pubmed/33473352
http://dx.doi.org/10.1016/j.toxrep.2020.12.019

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