CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice

Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment approaches are needed because current treatments do not target covalently closed circular DNA (cccDNA), the template for HBV replication, and rarely clear the virus. We harnessed adeno-associated virus (AAV) ve...

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Detalles Bibliográficos
Autores principales: Stone, Daniel, Long, Kelly R., Loprieno, Michelle A., De Silva Feelixge, Harshana S., Kenkel, Elizabeth J., Liley, R. Matt, Rapp, Stephen, Roychoudhury, Pavitra, Nguyen, Thuy, Stensland, Laurence, Colón-Thillet, Rossana, Klouser, Lindsay M., Weber, Nicholas D., Le, Connie, Wagoner, Jessica, Goecker, Erin A., Li, Alvason Zhenhua, Eichholz, Karsten, Corey, Lawrence, Tyrrell, D. Lorne, Greninger, Alexander L., Huang, Meei-Li, Polyak, Stephen J., Aubert, Martine, Sagartz, John E., Jerome, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803634/
https://www.ncbi.nlm.nih.gov/pubmed/33473359
http://dx.doi.org/10.1016/j.omtm.2020.11.014

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