Cargando…

Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice

Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, the role of the most suitable host cell for EV enrichment and preclinical str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, X., Zhang, L., Kuang, Y., Venkataramani, V., Jin, F., Hein, K., Zafeiriou, M. P., Lenz, C., Moebius, W., Kilic, E., Hermann, D. M., Weber, M. S., Urlaub, H., Zimmermann, W.-H., Bähr, M., Doeppner, Thorsten R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803677/ https://www.ncbi.nlm.nih.gov/pubmed/32361827 http://dx.doi.org/10.1007/s12975-020-00814-z

Ejemplares similares

Adipose‐derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR‐25
por: Kuang, Yaoyun, et al.
Publicado: (2020)

Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway
por: Zhang, Lin, et al.
Publicado: (2021)

Lithium modulates miR‐1906 levels of mesenchymal stem cell‐derived extracellular vesicles contributing to poststroke neuroprotection by toll‐like receptor 4 regulation
por: Haupt, Matteo, et al.
Publicado: (2020)

Concise Review: Extracellular Vesicles Overcoming Limitations of Cell Therapies in Ischemic Stroke
por: Doeppner, Thorsten R., et al.
Publicado: (2017)

Immunological and non-immunological effects of stem cell-derived extracellular vesicles on the ischaemic brain
por: Doeppner, Thorsten R., et al.
Publicado: (2018)

Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice
por: Zhang, Lin, et al.
Publicado: (2020)

Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke
por: Hermann, Dirk M., et al.
Publicado: (2022)

From Tumor Metastasis towards Cerebral Ischemia—Extracellular Vesicles as a General Concept of Intercellular Communication Processes
por: Zheng, Xuan, et al.
Publicado: (2019)

Effects of neural progenitor cells on post-stroke neurological impairment—a detailed and comprehensive analysis of behavioral tests
por: Doeppner, Thorsten R., et al.
Publicado: (2014)

Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation
por: Xin, Wenqiang, et al.
Publicado: (2023)

Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition
por: Doeppner, T R, et al.
Publicado: (2015)

Editorial: Stem cells and progenitor cells in ischemic stroke—fashion or future?
por: Doeppner, Thorsten R., et al.
Publicado: (2015)

CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age
por: Lieschke, Simone, et al.
Publicado: (2019)

Inhibition of Fatty Acid Synthesis Aggravates Brain Injury, Reduces Blood-Brain Barrier Integrity and Impairs Neurological Recovery in a Murine Stroke Model
por: Janssen, Lisa, et al.
Publicado: (2021)

Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia
por: Xin, Wen-Qiang, et al.
Publicado: (2021)

Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal
por: Doeppner, Thorsten R., et al.
Publicado: (2018)

Preconditioning Concepts for the Therapeutic Use of Extracellular Vesicles Against Stroke
por: Haupt, Matteo, et al.
Publicado: (2023)

Stem cell therapies in preclinical models of stroke associated with aging
por: Popa-Wagner, Aurel, et al.
Publicado: (2014)

Effects of acute versus post-acute systemic delivery of neural progenitor cells on neurological recovery and brain remodeling after focal cerebral ischemia in mice
por: Doeppner, T R, et al.
Publicado: (2014)

The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis
por: Jaeger, Hanna M., et al.
Publicado: (2015)

Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations
por: Klyachko, Natalia L., et al.
Publicado: (2020)

Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
por: Al-Omar, Maher T., et al.
Publicado: (2022)

Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing
por: Wang, Zhihao, et al.
Publicado: (2023)

Investigating the effects of IDO1, PTGS2, and TGF-β1 overexpression on immunomodulatory properties of hTERT-MSCs and their extracellular vesicles
por: Haghighitalab, Azadeh, et al.
Publicado: (2021)

Suppression of T cells by mesenchymal and cardiac progenitor cells is partly mediated via extracellular vesicles
por: van den Akker, F., et al.
Publicado: (2018)

Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
por: Wang, Chen, et al.
Publicado: (2021)

Lithium beyond psychiatric indications: the reincarnation of a new old drug
por: Haupt, Matteo, et al.
Publicado: (2021)

Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability
por: Doeppner, Thorsten R., et al.
Publicado: (2014)

Mesenchymal stem cells in the treatment of ischemic stroke: progress and possibilities
por: Doeppner, Thorsten R, et al.
Publicado: (2010)

Extracellular Vesicle-Induced Differentiation of Neural Stem Progenitor Cells
por: Stronati, Eleonora, et al.
Publicado: (2019)

Preservation techniques of stem cells extracellular vesicles: a gate for manufacturing of clinical grade therapeutic extracellular vesicles and long-term clinical trials
por: Bahr, Mohamed M., et al.
Publicado: (2020)

Characteristics of Extracellular Vesicles and Preclinical Testing Considerations Prior to Clinical Applications
por: Yoo, Min Heui, et al.
Publicado: (2022)

Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis
por: Thomas, Josephine M, et al.
Publicado: (2020)

Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
por: Mohamud Yusuf, Ayan, et al.
Publicado: (2022)

Quest for Quality in Translational Stroke Research—A New Dawn for Neuroprotection?
por: Haupt, Matteo, et al.
Publicado: (2022)

Neuroprotective Strategies for Ischemic Stroke—Future Perspectives
por: Haupt, Matteo, et al.
Publicado: (2023)

Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells
por: Ditte, Zuzana, et al.
Publicado: (2022)

Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
por: Ma, Yizhao, et al.
Publicado: (2021)

Neonatal Cardiovascular-Progenitor-Cell-Derived Extracellular Vesicles Activate YAP1 in Adult Cardiac Progenitor Cells
por: Ceja, Lourdes, et al.
Publicado: (2023)

Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles
por: Mohieldin, Ashraf M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c2s2e3g65mgraf89sbigk7dgec