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Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles

In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well...

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Autores principales: Sojahrood, A.J., Haghi, H., Karshafian, R., Kolios, M.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803687/
https://www.ncbi.nlm.nih.gov/pubmed/33360533
http://dx.doi.org/10.1016/j.ultsonch.2020.105405
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author Sojahrood, A.J.
Haghi, H.
Karshafian, R.
Kolios, M.C.
author_facet Sojahrood, A.J.
Haghi, H.
Karshafian, R.
Kolios, M.C.
author_sort Sojahrood, A.J.
collection PubMed
description In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well understood. Here, we investigate the nonlinear behavior of the LCMBs by analyzing their bifurcation structure as a function of acoustic pressure. We show that, the LC can enhance the generation of period 2 (P2), P3, higher order subharmonics (SH), superharmonics and chaos at very low excitation pressures (e.g. 1 kPa). For LCMBs sonicated by their SH resonance frequency and in line with experimental observations with increasing pressure, P2 oscillations exhibit three stages: generation at low acoustic pressures, disappearance and re-generation. Within non-destructive oscillation regimes and by pressure amplitude increase, LCMBs can also exhibit two saddle node (SN) bifurcations resulting in possible abrupt enhancement of the scattered pressure. The first SN resembles the pressure dependent resonance phenomenon in uncoated MBs and the second SN resembles the pressure dependent SH resonance. Depending on the initial surface tension of the LCMBs, the nonlinear behavior may also be suppressed for a wide range of excitation pressures.
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spelling pubmed-78036872021-01-22 Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles Sojahrood, A.J. Haghi, H. Karshafian, R. Kolios, M.C. Ultrason Sonochem Original Research Article In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well understood. Here, we investigate the nonlinear behavior of the LCMBs by analyzing their bifurcation structure as a function of acoustic pressure. We show that, the LC can enhance the generation of period 2 (P2), P3, higher order subharmonics (SH), superharmonics and chaos at very low excitation pressures (e.g. 1 kPa). For LCMBs sonicated by their SH resonance frequency and in line with experimental observations with increasing pressure, P2 oscillations exhibit three stages: generation at low acoustic pressures, disappearance and re-generation. Within non-destructive oscillation regimes and by pressure amplitude increase, LCMBs can also exhibit two saddle node (SN) bifurcations resulting in possible abrupt enhancement of the scattered pressure. The first SN resembles the pressure dependent resonance phenomenon in uncoated MBs and the second SN resembles the pressure dependent SH resonance. Depending on the initial surface tension of the LCMBs, the nonlinear behavior may also be suppressed for a wide range of excitation pressures. Elsevier 2020-12-08 /pmc/articles/PMC7803687/ /pubmed/33360533 http://dx.doi.org/10.1016/j.ultsonch.2020.105405 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research Article
Sojahrood, A.J.
Haghi, H.
Karshafian, R.
Kolios, M.C.
Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_full Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_fullStr Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_full_unstemmed Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_short Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_sort nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803687/
https://www.ncbi.nlm.nih.gov/pubmed/33360533
http://dx.doi.org/10.1016/j.ultsonch.2020.105405
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