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A real or apparent decrease in glomerular filtration rate in patients using olaparib?

PURPOSE: Olaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for ovarian and metastatic breast cancer. Increased serum creatinine levels have been observed in patients taking olaparib, but the underlying mechanism is unknown. This study aimed to investigate if patients receiving ol...

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Detalles Bibliográficos
Autores principales:	Bruin, M. A. C., Korse, C. M., van Wijnen, B., de Jong, V. M. T., Linn, S. C., van Triest, B., Rosing, H., Beijnen, J. H., van den Broek, D., Huitema, A. D. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Pharmacodynamics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803870/ https://www.ncbi.nlm.nih.gov/pubmed/33319340 http://dx.doi.org/10.1007/s00228-020-03070-0

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