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Night shift work is associated with an increased risk of asthma

INTRODUCTION: Shift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent or rotating night shifts, exposing this large p...

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Autores principales: Maidstone, Robert J, Turner, James, Vetter, Celine, Dashti, Hassan S, Saxena, Richa, Scheer, Frank A J L, Shea, Steven A, Kyle, Simon D, Lawlor, Deborah A, Loudon, Andrew S I, Blaikley, John F, Rutter, Martin K, Ray, David W, Durrington, Hannah Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803886/
https://www.ncbi.nlm.nih.gov/pubmed/33199525
http://dx.doi.org/10.1136/thoraxjnl-2020-215218
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author Maidstone, Robert J
Turner, James
Vetter, Celine
Dashti, Hassan S
Saxena, Richa
Scheer, Frank A J L
Shea, Steven A
Kyle, Simon D
Lawlor, Deborah A
Loudon, Andrew S I
Blaikley, John F
Rutter, Martin K
Ray, David W
Durrington, Hannah Jane
author_facet Maidstone, Robert J
Turner, James
Vetter, Celine
Dashti, Hassan S
Saxena, Richa
Scheer, Frank A J L
Shea, Steven A
Kyle, Simon D
Lawlor, Deborah A
Loudon, Andrew S I
Blaikley, John F
Rutter, Martin K
Ray, David W
Durrington, Hannah Jane
author_sort Maidstone, Robert J
collection PubMed
description INTRODUCTION: Shift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent or rotating night shifts, exposing this large population to the risk of circadian misalignment-driven disease. Analysis of the impact of shift work on chronic inflammatory diseases is lacking. We investigated the association between shift work and asthma. METHODS: We describe the cross-sectional relationship between shift work and prevalent asthma in >280000 UK Biobank participants, making adjustments for major confounding factors (smoking history, ethnicity, socioeconomic status, physical activity, body mass index). We also investigated chronotype. RESULTS: Compared with day workers, ‘permanent’ night shift workers had a higher likelihood of moderate-severe asthma (OR 1.36 (95% CI 1.03 to 1.8)) and all asthma (OR 1.23 (95% CI 1.03 to 1.46)). Individuals doing any type of shift work had higher adjusted odds of wheeze/whistling in the chest. Shift workers who never or rarely worked on nights and people working permanent nights had a higher adjusted likelihood of having reduced lung function (FEV(1) <80% predicted). We found an increase in the risk of moderate-severe asthma in morning chronotypes working irregular shifts, including nights (OR 1.55 (95% CI 1.06 to 2.27)). CONCLUSIONS: The public health implications of these findings are far-reaching due to the high prevalence and co-occurrence of both asthma and shift work. Future longitudinal follow-up studies are needed to determine if modifying shift work schedules to take into account chronotype might present a public health measure to reduce the risk of developing inflammatory diseases such as asthma.
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spelling pubmed-78038862021-01-21 Night shift work is associated with an increased risk of asthma Maidstone, Robert J Turner, James Vetter, Celine Dashti, Hassan S Saxena, Richa Scheer, Frank A J L Shea, Steven A Kyle, Simon D Lawlor, Deborah A Loudon, Andrew S I Blaikley, John F Rutter, Martin K Ray, David W Durrington, Hannah Jane Thorax Respiratory Epidemiology INTRODUCTION: Shift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent or rotating night shifts, exposing this large population to the risk of circadian misalignment-driven disease. Analysis of the impact of shift work on chronic inflammatory diseases is lacking. We investigated the association between shift work and asthma. METHODS: We describe the cross-sectional relationship between shift work and prevalent asthma in >280000 UK Biobank participants, making adjustments for major confounding factors (smoking history, ethnicity, socioeconomic status, physical activity, body mass index). We also investigated chronotype. RESULTS: Compared with day workers, ‘permanent’ night shift workers had a higher likelihood of moderate-severe asthma (OR 1.36 (95% CI 1.03 to 1.8)) and all asthma (OR 1.23 (95% CI 1.03 to 1.46)). Individuals doing any type of shift work had higher adjusted odds of wheeze/whistling in the chest. Shift workers who never or rarely worked on nights and people working permanent nights had a higher adjusted likelihood of having reduced lung function (FEV(1) <80% predicted). We found an increase in the risk of moderate-severe asthma in morning chronotypes working irregular shifts, including nights (OR 1.55 (95% CI 1.06 to 2.27)). CONCLUSIONS: The public health implications of these findings are far-reaching due to the high prevalence and co-occurrence of both asthma and shift work. Future longitudinal follow-up studies are needed to determine if modifying shift work schedules to take into account chronotype might present a public health measure to reduce the risk of developing inflammatory diseases such as asthma. BMJ Publishing Group 2021-01 2020-11-16 /pmc/articles/PMC7803886/ /pubmed/33199525 http://dx.doi.org/10.1136/thoraxjnl-2020-215218 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Respiratory Epidemiology
Maidstone, Robert J
Turner, James
Vetter, Celine
Dashti, Hassan S
Saxena, Richa
Scheer, Frank A J L
Shea, Steven A
Kyle, Simon D
Lawlor, Deborah A
Loudon, Andrew S I
Blaikley, John F
Rutter, Martin K
Ray, David W
Durrington, Hannah Jane
Night shift work is associated with an increased risk of asthma
title Night shift work is associated with an increased risk of asthma
title_full Night shift work is associated with an increased risk of asthma
title_fullStr Night shift work is associated with an increased risk of asthma
title_full_unstemmed Night shift work is associated with an increased risk of asthma
title_short Night shift work is associated with an increased risk of asthma
title_sort night shift work is associated with an increased risk of asthma
topic Respiratory Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803886/
https://www.ncbi.nlm.nih.gov/pubmed/33199525
http://dx.doi.org/10.1136/thoraxjnl-2020-215218
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